Guanabenz acetate

Description

Guanabenz acetate · CAS 23256-50-0 · C10H12Cl2N4O2. UNII 443O19GK1A. Melting Point: 227-229 °C (decomposition); Solubility: In water, 11 mg/ml @ 25 °C; Dissociation Constants: pKa = 8.1.

Identification

CAS Registry Number	23256-50-0
PubChem CID	5702062
Molecular formula	C10H12Cl2N4O2
IUPAC name	acetic acid;2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
UNII (FDA)	443O19GK1A

Computed Descriptors

Molecular Weight	291.13
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	290.0337310
Monoisotopic Mass	290.0337310
Topological Polar Surface Area	114
Heavy Atom Count	18
Formal Charge	0
Complexity	259

Physical & Chemical Properties

Melting Point	227-229 °C (decomposition)
Solubility	In water, 11 mg/ml @ 25 °C
Dissociation Constants	pKa = 8.1

Physical description & handling notes

• White solid from acetonitrile
• White to almost white powder
• Slight odor
• Solubility of 50 mg/ml in alcohol at 25 °C
• Solid; mp: 192.5 °C (decomposition); solubility at 25 °C (mg/ml): propylene glycol 100, chloroform 0.6, ethyl acetate 1 /Guanabenz monoacetate/
• Oral Tablets, 4 mg (of guanabenz), Wytensin, Wyeth; 8 mg (of guanabenz), Wytensin (scored), Wyeth.

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• Preparation: J. Yates, E. Haddock, GB 1019120 (1966 to Schell) ... Use as antihypertensive: W. J. Houlihan et al, DE 1804634 (1969 to Sandoz). /Guanabenz/
• Adrenergic alpha-Agonists; Antihypertensive Agents; Sympatholytics
• Guanabenz is used in the management of hypertension. The efficacy of guanabenz in hypertensive patients is similar to that of other adrenergic inhibitors such as clonidine, methyldopa, or beta-adrenergic blocking agents (eg, pindolol, propranolol).
• Guanabenz has been used alone or in combination with naltrexone in the management of opiate withdrawal in patients physically dependent on opiates and undergoing detoxification. Guanabenz has also been used as an analgesic in a limited number of patients with chronic pain; use of the drug permitted a reduction in opiate dosage or discontinuance of opiate therapy in these patients, but additional study is necessary. /Use is not currently included in the labeling approved by the FDA/
• For more Therapeutic Uses (Complete) data for GUANABENZ ACETATE (6 total), please visit the HSDB record page.
• Guanabenz should be used with caution and blood pressure monitored carefully in patients with hepatic and/or renal impairment, since the pharmacokinetics of the drug may be altered in such patients. The drug also should be used with caution in patients with severe coronary insufficiency, recent myocardial infarction, and/or cerebrovascular disease. Guanabenz should also be used with caution in geriatric patients since they may be more sensitive to the hypotensive and sedative effects of the drug.

Synonyms

Guanabenz acetate; 23256-50-0; Wytensin; WY-8678 acetate; Guanabenz monoacetate; 443O19GK1A; NSC-757044; Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, monoacetate; (E)-1-(2,6-Dichlorobenzylideneamino)guanidine monoacetate; 3-((2,6-Dichlorophenyl)methylene)carbazamidine monoacetate; Acetate, Guanabenz; Monoacetate, Guanabenz; RefChem:55289; Guanabenz Acetate Wyeth-Ayerst; Acetate Wyeth-Ayerst, Guanabenz; Wyeth Ayerst of Guanabenz Acetate

Frequently Asked Questions

What are the CAS number and molecular formula of Guanabenz acetate?

CAS 23256-50-0; molecular formula C10H12Cl2N4O2; molecular weight — g/mol.

What other names is Guanabenz acetate known by?

Guanabenz acetate, 23256-50-0, Wytensin, WY-8678 acetate, Guanabenz monoacetate, 443O19GK1A.

Is Guanabenz acetate classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of Guanabenz acetate?

Melting Point: 227-229 °C (decomposition); Solubility: In water, 11 mg/ml @ 25 °C; Dissociation Constants: pKa = 8.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.