Hydroxy Chloroquine

Description

Hydroxy Chloroquine · CAS 118-42-3 · C18H26ClN3O. UNII 4QWG6N8QKH. Melting Point: 89-91; Melting Point: 90 °C; Solubility: 2.61e-02 g/L.

Identification

CAS Registry Number	118-42-3
PubChem CID	3652
Molecular formula	C18H26ClN3O
IUPAC name	2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
UNII (FDA)	4QWG6N8QKH

Computed Descriptors

Molecular Weight	335.9
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	335.1764402
Monoisotopic Mass	335.1764402
Topological Polar Surface Area	48.4
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	89-91
Melting Point	90 °C
Solubility	2.61e-02 g/L
Dissociation Constants	9.67

Physical description & handling notes

• Solid
• 177.57 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 174.27 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 169.89 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 180.2 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Consumption (g per capita) in the USA (2002): 0.0819
• For the suppressive treatment and treatment of acute attacks of malaria due to <i>Plasmodium vivax</i>, <i>P. malariae</i>, <i>P. ovale</i>, and susceptible strains of <i>P. falciparum</i>. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.
• Hydroxychloroquine is indicated for the prophylaxis of malaria where chloroquine resistance is not reported, treatment of uncomplicated malaria (caused by _P. falciparum_, _P. malariae_, _P. ovale_, or _P. vivax_), chronic discoid lupus erythematosus, systemic lupus erythematosus, acute rheumatoid arthritis, and chronic rheumatoid arthritis.
• Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury.

Synonyms

hydroxychloroquine; 118-42-3; Oxichloroquine; Oxychlorochin; Hidroxicloroquina; oxichlorochine; Polirreumin; Hydroxychloroquinum; 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; Dolquine; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 4QWG6N8QKH; 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline; CHEBI:5801; NSC4375

Frequently Asked Questions

What are the CAS number and molecular formula of Hydroxy Chloroquine?

CAS 118-42-3; molecular formula C18H26ClN3O; molecular weight — g/mol.

What other names is Hydroxy Chloroquine known by?

hydroxychloroquine, 118-42-3, Oxichloroquine, Oxychlorochin, Hidroxicloroquina, oxichlorochine.

Is Hydroxy Chloroquine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Hydroxy Chloroquine?

Melting Point: 89-91; Melting Point: 90 °C; Solubility: 2.61e-02 g/L; Dissociation Constants: 9.67.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.