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Home › Product Catalog › LDK378 dihydrochloride

LDK378 dihydrochloride

CAS 1380575-43-8C28H36ClN5O3SMW 558.1

LDK378 dihydrochloride (CAS No. 1380575-43-8) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1380575-43-8
Molecular FormulaC28H36ClN5O3S
Molecular Weight558.1
LogP6.4
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of LDK378 dihydrochloride?

The CAS number of LDK378 dihydrochloride is 1380575-43-8.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of LDK378 dihydrochloride?

Main applications include Organic Chemicals.

How do I buy LDK378 dihydrochloride or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

LDK378 dihydrochloride · CAS 1380575-43-8 · C28H36ClN5O3S. UNII K418KG2GET.

Identification

CAS Registry Number1380575-43-8
PubChem CID57379345
Molecular formulaC28H36ClN5O3S
IUPAC name5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
UNII (FDA)K418KG2GET

Computed Descriptors

Molecular Weight558.1
XLogP36.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass557.2227389
Monoisotopic Mass557.2227389
Topological Polar Surface Area114
Heavy Atom Count38
Formal Charge0

Physical description & handling notes

  • 9.7 and 4.1

GHS Hazard Classification

Reported hazard statementsH302 (33.3%), H360 (16.7%), H372 (66.7%), H400 (16.7%), H410 (66.7%)

H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H360 (16.7%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Documented Uses

  • Ceritinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC). Ceritinib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
  • Ceritinib is approved to treat:
  • • Non-small cell lung cancer that is ALK positive and has metastasized (spread to other parts of the body). It is used in adults.
  • Ceritinib is also being studied in the treatment of other types of cancer.
  • Avoid grapefruit products. Grapefruit inhibits the CYP3A metabolism of ceritinib, which may increase its serum concentration.

Synonyms

ceritinib; 1032900-25-6; LDK378; ZYKADIA; LDK-378; NVP-LDK378-NX; LDK 378; K418KG2GET; ceritinibum; NVP-LDK-378-NX; CHEBI:78432; DTXSID10725373; RefChem:57924; DTXCID50676118; L01XE28; 811-457-8

Frequently Asked Questions

What are the CAS number and molecular formula of LDK378 dihydrochloride?

CAS 1380575-43-8; molecular formula C28H36ClN5O3S; molecular weight — g/mol.

What other names is LDK378 dihydrochloride known by?

ceritinib, 1032900-25-6, LDK378, ZYKADIA, LDK-378, NVP-LDK378-NX.

Is LDK378 dihydrochloride classified as hazardous?

Hazard statements reported: H302, H360, H372, H400, H410.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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