Lercanidipine

Description

Lercanidipine · CAS 100427-26-7 · C36H41N3O6. UNII V7XTJ4R0BH. Solubility: 1.56e-04 g/L; LogP: 6.4.

Identification

CAS Registry Number	100427-26-7
PubChem CID	65866
Molecular formula	C36H41N3O6
IUPAC name	5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	V7XTJ4R0BH

Computed Descriptors

Molecular Weight	611.7
XLogP3	6.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	13
Exact Mass	611.29953604
Monoisotopic Mass	611.29953604
Topological Polar Surface Area	114
Heavy Atom Count	45
Formal Charge	0

Physical & Chemical Properties

Solubility	1.56e-04 g/L
LogP	6.4

Physical description & handling notes

• Solid
• 249.8 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H360 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome
• Avoid alcohol. Alcohol may increase the vasodilatory effects of lercanidipine, which may lead to hypotension.
• Avoid grapefruit products. Grapefruit inhibits the metabolism of lercanidipine through CYP3A4, which causes increased serum levels of lercanidipine, and may increase the risk of hypotension.
• Exercise caution with St. John's Wort. Lercanidipine is metabolized by CYP3A4, and St. John's Wort is a CYP3A4 inducer.

Synonyms

Lercanidipine; 100427-26-7; Lercanil; V7XTJ4R0BH; Lercanidipino; DTXSID2048327; Lerdip; REC-15-2375; lercanidipinum; RefChem:152876; DTXCID7028302; C08CA13; Lercanidipine [INN]; Lercanidipine (INN); masnidipine; MFCD00867978

Frequently Asked Questions

What are the CAS number and molecular formula of Lercanidipine?

CAS 100427-26-7; molecular formula C36H41N3O6; molecular weight — g/mol.

What other names is Lercanidipine known by?

Lercanidipine, 100427-26-7, Lercanil, V7XTJ4R0BH, Lercanidipino, DTXSID2048327.

Is Lercanidipine classified as hazardous?

Hazard statements reported: H302, H360.

What are the key physical properties of Lercanidipine?

Solubility: 1.56e-04 g/L; LogP: 6.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.