左布诺洛尔

Description

Levobunolol · CAS 47141-42-4 · C17H25NO3. UNII G6317AOI7K. Melting Point: 209-211 °C; Melting Point: 209 - 211 °C; Solubility: 2.51e-01 g/L.

Identification

CAS Registry Number	47141-42-4
PubChem CID	39468
Molecular formula	C17H25NO3
IUPAC name	5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one
UNII (FDA)	G6317AOI7K

Computed Descriptors

Molecular Weight	291.4
XLogP3	2.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	291.18344366
Monoisotopic Mass	291.18344366
Topological Polar Surface Area	58.6
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	209-211 °C
Melting Point	209 - 211 °C
Solubility	2.51e-01 g/L
LogP	2.4
LogP	2.1

Physical description & handling notes

• Solid

Documented Uses

• For lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Adrenergic Beta-Antagonists; Antiglaucoma Agents; Antiarrhythmics
• Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
• Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
• Mechanisms of Action [MoA] - Adrenergic beta-Antagonists
• Established Pharmacologic Class [EPC] - beta-Adrenergic Blocker

Synonyms

LEVOBUNOLOL; 47141-42-4; Levobunololum; (-)-Bunolol; Bunolol, (s)-; Bunolol, (-)-; G6317AOI7K; (S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone; CHEBI:6438; DTXSID1043833; 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalen-1-one; 1(2H)-Naphthalenone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-, (S)-; levobunololo; ApoLevobunolol; NovoLevobunolol; PMSLevobunolol

Frequently Asked Questions

What are the CAS number and molecular formula of Levobunolol?

CAS 47141-42-4; molecular formula C17H25NO3; molecular weight — g/mol.

What other names is Levobunolol known by?

LEVOBUNOLOL, 47141-42-4, Levobunololum, (-)-Bunolol, Bunolol, (s)-, Bunolol, (-)-.

What are the key physical properties of Levobunolol?

Melting Point: 209-211 °C; Melting Point: 209 - 211 °C; Solubility: 2.51e-01 g/L; LogP: 2.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.