利马前列素

Description

Limaprost · CAS 74397-12-9 · C22H36O5. UNII L02U804092.

Identification

CAS Registry Number	74397-12-9
PubChem CID	6438378
Molecular formula	C22H36O5
IUPAC name	(E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-5-oxocyclopentyl]hept-2-enoic acid
UNII (FDA)	L02U804092

Computed Descriptors

Molecular Weight	380.5
XLogP3	4.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	13
Exact Mass	380.25627424
Monoisotopic Mass	380.25627424
Topological Polar Surface Area	94.8
Heavy Atom Count	27
Formal Charge	0

Physical description & handling notes

• Limaprost produces vasodilation to improve blood flow to the extremities and increase cutaneous temperature.

GHS Hazard Classification

Reported hazard statements	H300 (100%)

Documented Uses

• Limaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain and numbness of lower legs) and gait ability associated with acquired lumbar spinal canal stenosis (in patients with bilateral intermittent claudication showing normal SLR test result).
• B - Blood and blood forming organs
• B01AC - Platelet aggregation inhibitors excl. heparin
• QB - Blood and blood forming organs
• QB01AC - Platelet aggregation inhibitors, excl. heparin
• Limaprost reaches peak plasma concentration in about 30 minutes.

Synonyms

Limaprost; 74397-12-9; Limaprostum; L02U804092; DTXSID701018146; RefChem:153454; DTXCID401476393; Limaprost alpha-cyclodextrin clathrate; ONO 1206; Limaprost [INN]; (E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-5-oxocyclopentyl]hept-2-enoic acid; OP-1206; ONO-1206; (2E,11-alpha,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid; (E)-7-((1R,2R,3R)-3-hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)hept-2-enoic acid; Limaprost (INN)

Frequently Asked Questions

What are the CAS number and molecular formula of Limaprost?

CAS 74397-12-9; molecular formula C22H36O5; molecular weight — g/mol.

What other names is Limaprost known by?

Limaprost, 74397-12-9, Limaprostum, L02U804092, DTXSID701018146, RefChem:153454.

Is Limaprost classified as hazardous?

Hazard statements reported: H300.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.