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Description

Lometrexol · CAS 106400-81-1 · C21H25N5O6. UNII 6P3AVY8A7Q.

Identification

CAS Registry Number	106400-81-1
PubChem CID	135413518
Molecular formula	C21H25N5O6
IUPAC name	(2S)-2-[[4-[2-[(6R)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]amino]pentanedioic acid
UNII (FDA)	6P3AVY8A7Q

Computed Descriptors

Molecular Weight	443.5
XLogP3	0.3
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	443.18048353
Monoisotopic Mass	443.18048353
Topological Polar Surface Area	183
Heavy Atom Count	32
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• Antimetabolites that are useful in cancer chemotherapy.
• Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

Synonyms

Lometrexol; 106400-81-1; Lometrexolum; 5,10-dideazatetrahydrofolic acid; 6P3AVY8A7Q; LY264618; 5,10-dideazatetrahydrofolate; L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-; 5,10-Dideaza-5,6,7,8-tetrahydrofolic acid; NSC660025; 5,10-DDTF; RefChem:800022; (6R)-DDATHF; 6R-5,10-Dideazatetrahydrofolate; Pyrido(2,3-d)pyrimidine, L-glutamic acid derivative; DDATHF

Frequently Asked Questions

What are the CAS number and molecular formula of Lometrexol?

CAS 106400-81-1; molecular formula C21H25N5O6; molecular weight — g/mol.

What other names is Lometrexol known by?

Lometrexol, 106400-81-1, Lometrexolum, 5,10-dideazatetrahydrofolic acid, 6P3AVY8A7Q, LY264618.

Is Lometrexol classified as hazardous?

Hazard statements reported: H301.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.