Loteprednol Etabonate

Description

Loteprednol Etabonate · CAS 82034-46-6 · C24H31ClO7. UNII YEH1EZ96K6. Melting Point: 220-224 °C; LogP: 3.4.

Identification

CAS Registry Number	82034-46-6
PubChem CID	444025
Molecular formula	C24H31ClO7
IUPAC name	chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
UNII (FDA)	YEH1EZ96K6

Computed Descriptors

Molecular Weight	466.9
XLogP3	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	466.1758310
Monoisotopic Mass	466.1758310
Topological Polar Surface Area	99.1
Heavy Atom Count	32
Formal Charge	0

Physical & Chemical Properties

Melting Point	220-224 °C
LogP	3.4

Regulatory Status

GHS notification summary	25% (2 / 8)

GHS Hazard Classification

GHS notification summary	25% (2 / 8)
Reported hazard statements	H302 (12.5%), H312 (12.5%), H332 (12.5%), H361 (62.5%), H362 (50%), H373 (37.5%), H413 (12.5%)

Documented Uses

• A number of prescription loteprednol etabonate ophthalmic products are specifically indicated for the treatment of post-operative inflammation and pain following ocular surgery.
• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
• Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]
• Loteprednol etabonate (LE) demonstrates good ocular permeation properties as it is lipid soluble, allowing the agent to penetrate into cells with relative ease. Results from the ocular administration of loteprednol in normal, healthy volunteers have shown that there are low or undetectable concentrations of either unchanged material or its metabolite. Following twice-daily unilateral topical ocular dosing of LE for 14 days in healthy subjects, the plasma concentrations of loteprednol etabonate were below the limit
• Following systemic administration to rats, loteprednol etabonate is eliminated primarily via the biliary/faecal route, with most of the dose eliminated in the form of the metabolite, PJ-90.
• The only data available regarding the volume of distribution of loteprednol etabonate (LE) is the volume of distribution the agent demonstrated when administered to dogs - a value of 3.7 L/kg. It has been shown, however, that the topical ocular administration of LE distributes preferentially into the cellular components of blood.

Synonyms

Loteprednol etabonate; 82034-46-6; Lotemax; Alrex; HGP-1; Inveltys; CDDD-5604; P-5604; Airex; DTXSID2046468; CDDD 5604; YEH1EZ96K6; EYSUVIS; CDDD5604; CHEBI:31784; KPI-121

Frequently Asked Questions

What are the CAS number and molecular formula of Loteprednol Etabonate?

CAS 82034-46-6; molecular formula C24H31ClO7; molecular weight — g/mol.

What other names is Loteprednol Etabonate known by?

Loteprednol etabonate, 82034-46-6, Lotemax, Alrex, HGP-1, Inveltys.

Is Loteprednol Etabonate classified as hazardous?

25% of GHS notifications report no hazard classification (2 of 8).

What are the key physical properties of Loteprednol Etabonate?

Melting Point: 220-224 °C; LogP: 3.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.