loxapine

Description

loxapine · CAS 1977-10-2 · C18H18ClN3O. UNII LER583670J. Melting Point: 109-111 °C; Melting Point: 109-110 °C; Melting Point: 109 - 110 °C.

Identification

CAS Registry Number	1977-10-2
PubChem CID	3964
Molecular formula	C18H18ClN3O
IUPAC name	8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
UNII (FDA)	LER583670J

Computed Descriptors

Molecular Weight	327.8
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	327.1138399
Monoisotopic Mass	327.1138399
Topological Polar Surface Area	28.1
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	109-111 °C
Melting Point	109-110 °C
Melting Point	109 - 110 °C
Solubility	1.03e-01 g/L
LogP	3.6
LogP	3.86
Dissociation Constants	7.48
Dissociation Constants	7.5

Physical description & handling notes

• Solid
• Pale yellowish crystals from petroleum ether
• When heated to decomposition it emits very toxic fumes of /hydrogen chloride/ and nitroxides.
• 175.7 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 178.56 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 174.44 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• For the management of the manifestations of psychotic disorders such as schizophrenia
• Netherlands patent application 6,406,089 corresponds to Schmutz et al, US patent 3,546,226 (1964, 1970 both to Wander); Eidem, Helv Chim Acta 50, 245 (1967); Coppola, US patent 3,412,193 (1968 to American Cyanamid).
• Loxapine is a conventional antipsychotic used in the therapy of schizophrenia. Loxapine therapy is commonly associated with minor serum aminotransferase elevations and in very rare instances has been linked to clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antipsychotic Agents
• Loxapine (Class: Other Substances, Added Date: 07-2000)
• Antipsychotic Agents; Dopamine Antagonists

Synonyms

loxapine; 1977-10-2; Cloxazepine; Oxilapine; Loxapin; Adasuve; Loxapina; Loxapinum; Hydrofluoride 3170; CL-62362; SUM 3170; SUM-3170; HF 3170; LW 3170; Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-; CL 62362

Frequently Asked Questions

What are the CAS number and molecular formula of loxapine?

CAS 1977-10-2; molecular formula C18H18ClN3O; molecular weight — g/mol.

What other names is loxapine known by?

loxapine, 1977-10-2, Cloxazepine, Oxilapine, Loxapin, Adasuve.

Is loxapine classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of loxapine?

Melting Point: 109-111 °C; Melting Point: 109-110 °C; Melting Point: 109 - 110 °C; Solubility: 1.03e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.