马尼地平

Description

Manidipine · CAS 120092-68-4 · C35H38N4O6. UNII 6O4754US88. Solubility: <1mg/mL; LogP: 5.2.

Identification

CAS Registry Number	120092-68-4
PubChem CID	4008
Molecular formula	C35H38N4O6
IUPAC name	5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	6O4754US88

Computed Descriptors

Molecular Weight	610.7
XLogP3	5.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	610.27913494
Monoisotopic Mass	610.27913494
Topological Polar Surface Area	117
Heavy Atom Count	45
Formal Charge	0

Physical & Chemical Properties

Solubility	<1mg/mL
LogP	5.2

Physical description & handling notes

• Manidipine produces vasodilation resulting in lower blood pressure.

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• For the treatment of hypertension.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
• C08C - Selective calcium channel blockers with mainly vascular effects

Synonyms

manidipine; 89226-50-6; Franidipine; Artedil; Manidipine 6300; Manidipino; 6O4754US88; DTXSID2043745; manidipinum; manidipine, (+-)-; RefChem:809939; DTXCID0023745; C08CA11; 120092-68-4; Manidipine [INN]; MFCD00871291

Frequently Asked Questions

What are the CAS number and molecular formula of Manidipine?

CAS 120092-68-4; molecular formula C35H38N4O6; molecular weight — g/mol.

What other names is Manidipine known by?

manidipine, 89226-50-6, Franidipine, Artedil, Manidipine 6300, Manidipino.

Is Manidipine classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of Manidipine?

Solubility: <1mg/mL; LogP: 5.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.