美加明

Description

mecamylamine · CAS 60-40-2 · C11H21N. UNII 6EE945D3OK. Boiling Point: 72; Melting Point: 249; Melting Point: < 25 °C.

Identification

CAS Registry Number	60-40-2
PubChem CID	4032
Molecular formula	C11H21N
IUPAC name	N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
UNII (FDA)	6EE945D3OK

Computed Descriptors

Molecular Weight	167.29
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	167.167399674
Monoisotopic Mass	167.167399674
Topological Polar Surface Area	12
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Boiling Point	72
Melting Point	249
Melting Point	< 25 °C
Solubility	1.24e-01 g/L
LogP	2.7

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (100%), H315 (100%), H319 (100%), H332 (100%), H335 (100%)

Documented Uses

• For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
• Avoid excessive or chronic alcohol consumption. The ingestion of alcohol may potentiate the actions of mecamylamine.
• Take after a meal. This slows mecamylamine absorption allowing for a gradual reduction in blood pressure. Take consistently at the same time in regard to meals.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
• Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.

Synonyms

mecamylamine; Versamine; Mecamilamina; 60-40-2; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine; Mecamylaminum; DTXSID0023240; Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-; DTXCID903240; Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-; N,2,3,3-tetramethylbicyclo(2.2.1)heptan-2-amine; RefChem:56912; C02BB01; 200-476-1; (1RS,2SR,4SR)-N,2,3,3-Tetramethylbicyclo(2.2.1)heptan-2-amine; 6EE945D3OK

Frequently Asked Questions

What are the CAS number and molecular formula of mecamylamine?

CAS 60-40-2; molecular formula C11H21N; molecular weight — g/mol.

What other names is mecamylamine known by?

mecamylamine, Versamine, Mecamilamina, 60-40-2, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine, Mecamylaminum.

Is mecamylamine classified as hazardous?

Hazard statements reported: H302, H312, H315, H319, H332.

What are the key physical properties of mecamylamine?

Boiling Point: 72; Melting Point: 249; Melting Point: < 25 °C; Solubility: 1.24e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.