Mefloquine

Description

Mefloquine · CAS 53230-10-7 · C17H16F6N2O. UNII TML814419R. Boiling Point: 415.7±40.0 °C; Melting Point: 250-254; Melting Point: 174-176 °C.

Identification

CAS Registry Number	53230-10-7
PubChem CID	4046
Molecular formula	C17H16F6N2O
IUPAC name	[2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol
UNII (FDA)	TML814419R

Computed Descriptors

Molecular Weight	378.31
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Exact Mass	378.11668211
Monoisotopic Mass	378.11668211
Topological Polar Surface Area	45.2
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Boiling Point	415.7±40.0 °C
Melting Point	250-254
Melting Point	174-176 °C
Solubility	1.806
Solubility	3.80e-02 g/L
LogP	3.9
Dissociation Constants	8.6

Physical description & handling notes

• Solid
• Crystal density: 1.432 g/cu cm
• Stable under recommended storage conditions. /Mefloquine hydrochloride/
• 180.17 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 183.89 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 176.86 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Preparation of erythro-form: G. Grethe, T. Mitt, German patent 2806909; H. Bomches, B. Hardegger, United States of America patent 4507482 (1978, 1985 both to Hoffman-La Roche).
• A 250 mg tablet is equivalent to 228 mg of mefloquine base. The product available in Canada and other countries is 250 mg of mefloquine base, equivalent to 274 mg of mefloquine hydrochloride.
• Mefloquine is indicated for the treatment of mild to moderate cases of malaria caused by Plasmodium falciparum and Plasmodium vivax. It is effective against chloroquine-resistant forms of Plasmodium falciparum. Mefloquine is also indicated for the prophylaxis of malaria caused by Plasmodium falciparum and Plasmodium vivax, including chloroquine-resistant forms of Plasmodium falciparum.
• Mefloquine is a quinoline derivative used for the prevention and therapy of P. falciparum malaria. Mefloquine therapy is associated with a low rate of transient and asymptomatic serum enzyme elevations and is a rare cause of clinically apparent acute liver injury.

Synonyms

mefloquine; Mefloquina; 53230-10-7; GNF-Pf-5544; Racemic mefloquine; [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol; Mefloquinum; Ro-215998; NSC-758233; Ro 21-5998; WR 142,490; DTXSID4037168; Mephloquine; (2,8-bis(trifluoromethyl)quinolin-4-yl)-piperidin-2-ylmethanol; RefChem:56342; CHEBI:63609

Frequently Asked Questions

What are the CAS number and molecular formula of Mefloquine?

CAS 53230-10-7; molecular formula C17H16F6N2O; molecular weight — g/mol.

What other names is Mefloquine known by?

mefloquine, Mefloquina, 53230-10-7, GNF-Pf-5544, Racemic mefloquine, [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol.

Is Mefloquine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Mefloquine?

Boiling Point: 415.7±40.0 °C; Melting Point: 250-254; Melting Point: 174-176 °C; Solubility: 1.806.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.