甲地孕酮

Description

megestrol · CAS 3562-63-8 · C22H30O3. UNII EA6LD1M70M. Collision Cross Section: 198.71 Ų [M+H]+; Collision Cross Section: 202.21 Ų [M+Cl]-.

Identification

CAS Registry Number	3562-63-8
PubChem CID	19090
Molecular formula	C22H30O3
IUPAC name	(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
UNII (FDA)	EA6LD1M70M

Computed Descriptors

Molecular Weight	342.5
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	342.21949481
Monoisotopic Mass	342.21949481
Topological Polar Surface Area	54.4
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Collision Cross Section	198.71 Ų [M+H]+
Collision Cross Section	202.21 Ų [M+Cl]-

Physical description & handling notes

• Odorless
• Tasteless
• WHITE OR ALMOST WHITE, CRYSTALLINE POWDER; SPARINGLY SOL IN ALC; SLIGHTLY SOL IN ETHER & FIXED OILS; SOL IN ACETONE; VERY SOL IN CHLOROFORM /ACETATE/
• Crystals. MW: 384.50, mp 214-216 °C. Soluble in water. /Megestrol acetate/
• Megestrol acetate is commercially available as oral tablets and as oral suspensions; the 2 concentrations of the oral suspensions differ in formulation and are not bioequivalent.
• NIAGESTIN, OVABAN. MIXT WITH ETHYNYLESTRADIOL: CO-ERVONUM, KOMBIQUENS, NOVAL, NUVACON, OVEX, PLANOVIN, TRI-ERVONUM, VOLIDAN, WERADYS; MIXT WITH MESTRANOL: DELPREGNIN. /MEGESTROL ACETATE/

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• Consumption (g per capita) in the USA (2002): 0.019
• ... Prepared by oxidation of 17alpha-acetoxy-3beta-hydroxy-6-methylpregn-5-en-20-one with aluminium tert-butoxide and para-quinone in dry benzene. /Megestrol acetate/
• Reported impurities include: 6,17a-dimethyl-3,17-dioxo-D-homoandrosta-4,6-dien-17aalpha-yl acetate (D-homo megestrol acetate), 6alpha-methyl-3,20-dioxopregn-4-en-17-yl acetate (medroxyprogesterone acetate), 6-methyl-3,20-dioxopregna-1,4,6-trien-17-yl acetate, 6-methylene-3,20-dioxopregn-4-en-17-yl acetate (6-methylene hydroxyprogesterone acetate) and 6-methyl-17-hydroxypregna-4,6-diene-3,20-dione (megestrol). /Megestrol acetate/
• Megestrol acetate is a synthetic progestin which differs structurally from progesterone only in the addition of a 6-methyl group on the B ring, a 17-acetoxy group on the D ring of the steroid nucleus, and the addition of a 6-7 double bond.

Synonyms

megestrol; 3562-63-8; Megestrolo; Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-; Chronopil; Megestrolum; EA6LD1M70M; DTXSID001009330; CHEBI:6722; Compound 5071; RefChem:55564; G03AC05; G03DB02; L02AB01; DTXCID001436159; 222-628-6

Frequently Asked Questions

What are the CAS number and molecular formula of megestrol?

CAS 3562-63-8; molecular formula C22H30O3; molecular weight — g/mol.

What other names is megestrol known by?

megestrol, 3562-63-8, Megestrolo, Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, Chronopil, Megestrolum.

What are the key physical properties of megestrol?

Collision Cross Section: 198.71 Ų [M+H]+; Collision Cross Section: 202.21 Ų [M+Cl]-.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.