Mephentermine

Description

Mephentermine · CAS 100-92-5 · C11H17N. UNII TEZ91L71V4. Melting Point: < 25 °C; Solubility: 4.57e-01 g/L; Dissociation Constants: 10.37.

Identification

CAS Registry Number	100-92-5
PubChem CID	3677
Molecular formula	C11H17N
IUPAC name	N,2-dimethyl-1-phenylpropan-2-amine
UNII (FDA)	TEZ91L71V4

Computed Descriptors

Molecular Weight	163.26
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Exact Mass	163.136099547
Monoisotopic Mass	163.136099547
Topological Polar Surface Area	12
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Melting Point	< 25 °C
Solubility	4.57e-01 g/L
Dissociation Constants	10.37
Dissociation Constants	PKA: 10.38

Physical description & handling notes

• Solid
• LIQUID
• FISHY AMINE ODOR
• YELLOW CRYSTALS; MP: 155-156 °C /PICRATE/
• 1 G DISSOLVES IN 20 ML WATER, ABOUT 150 ML ETHANOL (95%); PRACTICALLY INSOL IN CHLOROFORM /SULFATE DIHYDRATE/
• FREELY SOL IN ALCOHOL; SOL IN ETHER; PRACTICALLY INSOL IN WATER

GHS Hazard Classification

Reported hazard statements	H336 (100%)

Documented Uses

• PREPARED BY HYDROGENATING 1-CHLORO-2-METHYLAMINO -2-METHYL-1-PHENYLPROPANE HYDROCHLORIDE IN METHANOL IN THE PRESENCE OF PALLADIUM BARIUM CARBONATE.
• Mephentermine is manufactured on a commercial scale by the reaction of a benzyl Grignard reagent with N-methylisopropylideneamine.
• THE FREE BASE IS SUFFICIENTLY VOLATILE THAT IT CAN BE USED IN INHALERS, WHICH IS THE ONLY TYPE OF PRODUCT OF THE FREE BASE THAT IS MARKETED.
• Used to maintain blood pressure in hypotensive states.
• Mephentermine (Class: Stimulants, Added Date: 10-1998)
• Adrenergic alpha-Agonists; Adrenergic Agents; Sympathomimetics; Vasoconstrictor Agents

Synonyms

MEPHENTERMINE; Mephenterdrine; Mephenterdrinum; Mefenterdrin; Mefentermin; Mephetedrine; Mephine; Vialin; N-Methylphentermine; Wyfentermina; Wyamine; 100-92-5; Mefentermina; Mephenterminum; 2-Methylamino-2-methyl-1-phenylpropane; WY-585

Frequently Asked Questions

What are the CAS number and molecular formula of Mephentermine?

CAS 100-92-5; molecular formula C11H17N; molecular weight — g/mol.

What other names is Mephentermine known by?

MEPHENTERMINE, Mephenterdrine, Mephenterdrinum, Mefenterdrin, Mefentermin, Mephetedrine.

Is Mephentermine classified as hazardous?

Hazard statements reported: H336.

What are the key physical properties of Mephentermine?

Melting Point: < 25 °C; Solubility: 4.57e-01 g/L; Dissociation Constants: 10.37; Dissociation Constants: PKA: 10.38.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.