Meropenem

Description

Meropenem · CAS 96036-03-2 · C17H25N3O5S. UNII YOP6PX0BAO. Solubility: 5.63e+00 g/L; LogP: -0.6; Collision Cross Section: 192.42 Ų [M-H]-.

Identification

CAS Registry Number	96036-03-2
PubChem CID	441130
Molecular formula	C17H25N3O5S
IUPAC name	(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
UNII (FDA)	YOP6PX0BAO

Computed Descriptors

Molecular Weight	383.5
XLogP3	-2.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	383.15149208
Monoisotopic Mass	383.15149208
Topological Polar Surface Area	135
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Solubility	5.63e+00 g/L
LogP	-0.6
Collision Cross Section	192.42 Ų [M-H]-
Collision Cross Section	190.79 Ų [M+H]+

Physical description & handling notes

• Solid
• Sparingly
• Freshly prepared solutions of Meropenem should be used whenever possible. However, constituted solutions of Meropenem maintain satisfactory potency at controlled room temperature 15-25 °C (59-77 °F) or under refrigeration at 4 °C (39 °F) ... . Solutions of intravenous Meropenem should not be frozen.
• Meropenem injection vials constituted with sterile Water for Injection for bolus administration (up to 50 mg/mL of Meropenem) may be stored for up to 2 hours at controlled room temperature 15-25 °C (59-77 °F) or for up to 12 hours at 4 °C (39 °F).
• White to pale yellow crystalline powder. Sparingly soluble in water; very slightly soluble in hydrated ethanol /Meropenem trihydrate/
• The solution varies from colorless to yellow depending on the concentration. The pH of freshly constituted solutions is between 7.3 and 8.3. Meropenem is soluble in 5% monobasic potassium phosphate solution ... and practically insoluble in acetone or ether. /Meropenem trihydrate/

GHS Hazard Classification

Reported hazard statements	H315 (76.9%), H317 (23.1%), H319 (76.9%), H334 (23.1%), H335 (76.9%)

Documented Uses

• Use (kg) in Switzerland (2009): >100
• Use (kg; approx.) in Germany (2009): >2500
• Use (kg; exact) in Germany (2009): 3586
• Consumption (g per capita) in Switzerland (2009): 0.013
• Consumption (g per capita; approx.) in Germany (2009): 0.031
• Consumption (g per capita; exact) in Germany (2009): 0.044

Synonyms

meropenem; 96036-03-2; Merrem; Meropenem anhydrous; Meropenemum; Antibiotic SM 7338; MERONEM; Merrem I.V.; MEPM; SM-7338; Meropenem, anhydrous; ICI-194660; DTXSID7045526; YOP6PX0BAO; CHEBI:43968; Merrem IV

Frequently Asked Questions

What are the CAS number and molecular formula of Meropenem?

CAS 96036-03-2; molecular formula C17H25N3O5S; molecular weight — g/mol.

What other names is Meropenem known by?

meropenem, 96036-03-2, Merrem, Meropenem anhydrous, Meropenemum, Antibiotic SM 7338.

Is Meropenem classified as hazardous?

Hazard statements reported: H315, H317, H319, H334, H335.

What are the key physical properties of Meropenem?

Solubility: 5.63e+00 g/L; LogP: -0.6; Collision Cross Section: 192.42 Ų [M-H]-; Collision Cross Section: 190.79 Ų [M+H]+.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.