Milrinone

Description

Milrinone · CAS 78415-72-2 · C12H9N3O. UNII JU9YAX04C7. Melting Point: >300 °C; Melting Point: > 300 °C; Solubility: <1 mg/mL.

Identification

CAS Registry Number	78415-72-2
PubChem CID	4197
Molecular formula	C12H9N3O
IUPAC name	6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
UNII (FDA)	JU9YAX04C7

Computed Descriptors

Molecular Weight	211.22
XLogP3	0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	211.074561919
Monoisotopic Mass	211.074561919
Topological Polar Surface Area	65.8
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	>300 °C
Melting Point	> 300 °C
Solubility	<1 mg/mL
Solubility	2.09e-01 g/L
LogP	0.4
LogP	0.42

Physical description & handling notes

• Solid
• 157.1 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID5023324]
• 156.3 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID5023324]
• 147.4 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID5023324]
• 150.4 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H301, H311, H331 (38.4%)

Documented Uses

• Consumption (g per capita) in the USA (2002): 3.53e-05
• Milrinone is indicated for the short-term (48 hours or less) treatment of patients with acute decompensated heart failure. Milrinone administration should occur together with close monitoring using appropriate electrocardiographic equipment and should occur in a facility equipped for the immediate treatment of potential cardiac events, including ventricular arrhythmias.
• Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
• Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
• Drugs used to cause dilation of the blood vessels.
• Compounds that specifically inhibit PHOSPHODIESTERASE 3.

Synonyms

milrinone; 78415-72-2; Milrila; Milrinona; Milrinonum; Win-47203-2; 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; DTXSID5023324; 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile; JU9YAX04C7; WIN 47203; NSC-760072; WIN 47,203-2; (3,4'-BIPYRIDINE)-5-CARBONITRILE, 1,6-DIHYDRO-2-METHYL-6-OXO-; DTXCID103324; Corotrop

Frequently Asked Questions

What are the CAS number and molecular formula of Milrinone?

CAS 78415-72-2; molecular formula C12H9N3O; molecular weight — g/mol.

What other names is Milrinone known by?

milrinone, 78415-72-2, Milrila, Milrinona, Milrinonum, Win-47203-2.

Is Milrinone classified as hazardous?

Hazard statements reported: H301, H311, H331.

What are the key physical properties of Milrinone?

Melting Point: >300 °C; Melting Point: > 300 °C; Solubility: <1 mg/mL; Solubility: 2.09e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.