盐酸米托蒽醌

Description

Mitoxantrone hydrochloride · CAS 70476-82-3 · C22H30Cl2N4O6. UNII U6USW86RD0. Melting Point: 203-5 °C; Solubility: H2O 5- 10 (mg/mL); Solubility: 0.1NHCl 1 - 3 (mg/mL).

Identification

CAS Registry Number	70476-82-3
PubChem CID	51082
Molecular formula	C22H30Cl2N4O6
IUPAC name	1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride
UNII (FDA)	U6USW86RD0

Computed Descriptors

Molecular Weight	517.4
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	12
Exact Mass	516.1542401
Monoisotopic Mass	516.1542401
Topological Polar Surface Area	163
Heavy Atom Count	34
Formal Charge	0
Complexity	571

Physical & Chemical Properties

Melting Point	203-5 °C
Solubility	H2O 5- 10 (mg/mL)
Solubility	0.1NHCl 1 - 3 (mg/mL)
Solubility	10% Ethanol 3 - 5 (mg/mL)
Solubility	95% Ethanol < 1 (mg/mL)
Solubility	Methanol < 1 (mg/mL)

Physical description & handling notes

• Crystals; [Merck Index]
• Blue-black solid from water ethanol
• Sparingly soluble in water; slightly sol in methanol; practically insoluble in acetonitrile chloroform; acetone
• pH 4 Acetate buffer 3 - 5 (mg/mL)
• pH 9 Borate buffer < 1 (mg/mL)
• 0.1 N NaOH decomposes (mg/mL)

GHS Hazard Classification

Reported hazard statements	H340 (92.9%), H360 (92.9%), H302, H310, H341, H351, H370, H372

Documented Uses

• Used as an antineoplastic drug; [Merck Index]
• DNA binding or cleaving agent used to treat acute nonlymphocytic leukemia, including myclogenous, promyclocytic, monocytic, and erythroid acute leukemias
• /Mitoxantrone's/ range of antitumor activity is confined to leukemias, breast cancer, and prostate cancer. ... It also is used as a component of experimental high-dose chemotherapy regimens, with uncertain efficacy.
• Consumption (g per capita) in the USA (2002): 2.34e-06
• Mitoxantrone hydrochloride is approved to be used with other drugs to treat:
• • Acute non-lymphocytic leukemia in adults.

Synonyms

70476-82-3; Mitoxantrone hydrochloride; Mitoxantrone dihydrochloride; CL-232315; Onkotrone; DTXSID0045173; Mitozantrone hydrochloride; CL 232,315; U6USW86RD0; NSC-301739; CL 232315; DTXCID8025173; CHEBI:50727; 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthraquinone dihydrochloride; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-, dihydrochloride; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride

Frequently Asked Questions

What are the CAS number and molecular formula of Mitoxantrone hydrochloride?

CAS 70476-82-3; molecular formula C22H30Cl2N4O6; molecular weight — g/mol.

What other names is Mitoxantrone hydrochloride known by?

70476-82-3, Mitoxantrone hydrochloride, Mitoxantrone dihydrochloride, CL-232315, Onkotrone, DTXSID0045173.

Is Mitoxantrone hydrochloride classified as hazardous?

Hazard statements reported: H340, H360, H302, H310, H341.

What are the key physical properties of Mitoxantrone hydrochloride?

Melting Point: 203-5 °C; Solubility: H2O 5- 10 (mg/mL); Solubility: 0.1NHCl 1 - 3 (mg/mL); Solubility: 10% Ethanol 3 - 5 (mg/mL).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.