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Home › Product Catalog › N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

CAS 391209-97-5C16H14F3IN2O4MW 482.19

N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide (CAS No. 391209-97-5) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number391209-97-5
Molecular FormulaC16H14F3IN2O4
Molecular Weight482.19
LogP3
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?

The CAS number of N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide is 391209-97-5.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?

Main applications include Organic Chemicals.

How do I buy N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide · CAS 391209-97-5 · C16H14F3IN2O4. UNII 86K0J5AK6M. Dissociation Constants: 7.96.

Identification

CAS Registry Number391209-97-5
PubChem CID9826528
Molecular formulaC16H14F3IN2O4
IUPAC nameN-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
UNII (FDA)86K0J5AK6M

Computed Descriptors

Molecular Weight482.19
XLogP33
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass481.99504
Monoisotopic Mass481.99504
Topological Polar Surface Area90.8
Heavy Atom Count26
Formal Charge0

Physical & Chemical Properties

Dissociation Constants7.96

Physical description & handling notes

  • In a mouse model of NF1, oral dosing of mirdametinib inhibited ERK phosphorylation and reduced neurofibroma tumour volume and proliferation.

GHS Hazard Classification

Reported hazard statementsH301 (97.5%), H373 (97.5%), H400 (95%), H410 (97.5%)

H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]

H373 (97.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Documented Uses

  • Mirdametinib is indicated for the treatment of neurofibromatosis type 1 (NF1) in patients two years and older with symptomatic plexiform neurofibromas (PN) that are not amenable to complete resection.
  • Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; MEK inhibitors
  • Take with or without food. Food has no clinically significant effects on drug exposure.
  • Agents that inhibit PROTEIN KINASES.
  • Established Pharmacologic Class [EPC] - Kinase Inhibitor
  • Mechanisms of Action [MoA] - Mitogen-Activated Protein Kinase Kinase 1 Inhibitors

Synonyms

391210-10-9; Mirdametinib; PD0325901; PD 0325901; PD-0325901; N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide; GOMEKLI; PD 325901; 86K0J5AK6M; DTXSID0044024; DTXCID8024024; CHEBI:88249; Pd 901; PD-901; Benzamide, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-; PD-03525901

Frequently Asked Questions

What are the CAS number and molecular formula of N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?

CAS 391209-97-5; molecular formula C16H14F3IN2O4; molecular weight — g/mol.

What other names is N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide known by?

391210-10-9, Mirdametinib, PD0325901, PD 0325901, PD-0325901, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide.

Is N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide classified as hazardous?

Hazard statements reported: H301, H373, H400, H410.

What are the key physical properties of N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?

Dissociation Constants: 7.96.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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