N-3,4-二甲基异恶唑-5-基-N-磺酰基乙酰胺

Description

N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide · CAS 80-74-0 · C13H15N3O4S. UNII WBT5QH3KED. Melting Point: 192.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• 161.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Documented Uses

• Readily absorbed from the gastrointestinal tract. In a pharmacokinetic study, the adjustments for variable renal clearances between oral and intravenous administration and using the unbound plasma concentrations, the bioavailability for an oral dose of sulfisoxazole was found to be 0.95 +/- 0.04.
• The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is the parent drug, and the remaining as the N4-acetylated metabolite. It is excreted in human milk. Sulfisoxazole and its acetylated metabolites are excreted primarily by the kidneys through glomerular filtration.
• The sulfonamides are widely distributed throughout all body tissues. It readily crosses the placental barrier and enters into fetal circulation and also crosses the blood-brain barrier. In healthy subjects, cerebrospinal fluid concentrations of sulfisoxazole vary; in patients with meningitis, however, concentrations of free drug in cerebrospinal fluid as high as 94 mcg/mL have been reported. In a pharmacokinetic study, the apparent volume of distribution for total drug was 10.9 +/- 2.0 liters and 136 +/- 36 liters
• The clearance of sulfisoxazole is 18.7 +/- 3.9 ml/min for total drug and 232 +/- 64 ml/min for the unbound drug.
• Approximately 85% of a dose of sulfisoxazole is bound to plasma proteins, primarily to albumin; 65% to 72% of the unbound portion is in the nonacetylated form.
• The serum half-life is 10 -12 hours.

Synonyms

Sulfisoxazole acetyl; 80-74-0; ACETYL SULFISOXAZOLE; Lipo Gantrisin; acetylsulfafurazole; Acetylsulfisoxazole; GANTRISIN PEDIATRIC; Acetyl sulfafurazole; Sulfafurazole acetyl; Sulfisoxizole acetyl; WBT5QH3KED; NSC-759138; Sulfisoxazole acetyl (USP); Sulfisoxazole acetyl [USP]; N-3,4-Dimethylisoxazol-5-yl-N-sulphanilylacetamide; Acetamide, N-((4-aminophenyl)sulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)-

Frequently Asked Questions

What are the CAS number and molecular formula of N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide?

CAS 80-74-0; molecular formula C13H15N3O4S; molecular weight — g/mol.

What other names is N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide known by?

Sulfisoxazole acetyl, 80-74-0, ACETYL SULFISOXAZOLE, Lipo Gantrisin, acetylsulfafurazole, Acetylsulfisoxazole.

What are the key physical properties of N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide?

Melting Point: 192.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.