N,N'-二异丙基碳二亚胺

Description

N,N'-Diisopropylcarbodiimide · CAS 693-13-0 · C7H14N2. UNII OQO20I6TWH. Boiling Point: 147 °C; Density: 0.806 g/cu cm at 25 °C; Vapor Pressure: 9.79 [mmHg].

Identification

CAS Registry Number	693-13-0
PubChem CID	12734
Molecular formula	C7H14N2
IUPAC name	N,N'-di(propan-2-yl)methanediimine
UNII (FDA)	OQO20I6TWH

Computed Descriptors

Molecular Weight	126.20
XLogP3	2.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	126.115698455
Monoisotopic Mass	126.115698455
Topological Polar Surface Area	24.7
Heavy Atom Count	9
Formal Charge	0

Physical & Chemical Properties

Boiling Point	147 °C
Density	0.806 g/cu cm at 25 °C
Vapor Pressure	9.79 [mmHg]
Vapor Pressure	5.1 mm Hg at 25 °C

Physical description & handling notes

• Colorless liquid; [Merck Index]
• Colorless liquid
• Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide, and tetrahydrofuran
• When heated to decomposition it emits toxic fumes of /oxides of nitrogen/.
• Index of Refraction = 1.4320 at 20 °C
• Flammable; Reacts with water to form 1,3-diisopropylurea

GHS Hazard Classification

Reported hazard statements	H226 (100%), H315 (98.6%), H317 (100%), H318 (99.5%), H330 (97.7%), H334 (100%), H335 (97.7%), H400 (13.8%)

Documented Uses

• Used as a reagent in synthetic organic chemistry; [Merck Index] Used as a chemical intermediate and as a stabilizer for Sarin (chemical weapon); [HSDB]
• Diisopropylcarbodiimide is used as a reagent for peptide syntheses and as a chemical intermediate. ... /Used/ in chemical, pharmaceutical, and recombinant DNA industries.
• Diisopropylcarbodiimide is a useful reagent for peptide syntheses, especially solid-phase peptide synthesis. In addition, diisopropylcarbodiimide is used as a chemical intermediate in the synthesis of N-silylformamides and in the preparation of polyimide precursor coatings for electrophoretic image display fabrication. Also used as a stabilizer for the military nerve agent Sarin.
• A peptide coupler commonly used in biotechnology.
• The current link for Diisopropylcarbodiimide is used as a reagent for peptide syntheses … is broken. The link and wording could be updated as follows: "Available from, as of November 12, 2025: ."
• 2-Propanamine, N,N'-methanetetraylbis-: ACTIVE

Synonyms

N,N'-Diisopropylcarbodiimide; 693-13-0; Diisopropylcarbodiimide; 1,3-Diisopropylcarbodiimide; 2-Propanamine, N,N'-methanetetraylbis-; DIPC; N,N'-METHANETETRAYLBIS-2-PROPANAMINE; DTXSID4025086; CHEBI:53092; OQO20I6TWH; dipropan-2-ylmethanediimine; NSC-42080; DTXCID305086; CARBODIIMIDE, DIISOPROPYL; RefChem:72688; 211-743-7

Frequently Asked Questions

What are the CAS number and molecular formula of N,N'-Diisopropylcarbodiimide?

CAS 693-13-0; molecular formula C7H14N2; molecular weight — g/mol.

What other names is N,N'-Diisopropylcarbodiimide known by?

N,N'-Diisopropylcarbodiimide, 693-13-0, Diisopropylcarbodiimide, 1,3-Diisopropylcarbodiimide, 2-Propanamine, N,N'-methanetetraylbis-, DIPC.

Is N,N'-Diisopropylcarbodiimide classified as hazardous?

Hazard statements reported: H226, H315, H317, H318, H330.

What are the key physical properties of N,N'-Diisopropylcarbodiimide?

Boiling Point: 147 °C; Density: 0.806 g/cu cm at 25 °C; Vapor Pressure: 9.79 [mmHg]; Vapor Pressure: 5.1 mm Hg at 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.