Nalidixic acid

Description

Nalidixic acid · CAS 389-08-2 · C12H12N2O3. UNII 3B91HWA56M. Melting Point: 444 to 446 °F (NTP, 1992); Melting Point: 229.5; Melting Point: 229-230 °C.

Identification

CAS Registry Number	389-08-2
PubChem CID	4421
Molecular formula	C12H12N2O3
IUPAC name	1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
UNII (FDA)	3B91HWA56M

Computed Descriptors

Molecular Weight	232.23
XLogP3	1.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	232.08479225
Monoisotopic Mass	232.08479225
Topological Polar Surface Area	70.5
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	444 to 446 °F (NTP, 1992)
Melting Point	229.5
Melting Point	229-230 °C
Melting Point	229.5 °C
Solubility	100
Solubility	2.30e+00 g/L
LogP	1.59
LogP	log Kow= 1.41
LogP	2.1
LogP	0.62

Physical description & handling notes

• Nalidixic acid is a cream-colored powder. (NTP, 1992)
• Solid
• PALE BUFF, CRYSTALLINE POWDER
• WHITE TO SLIGHTLY YELLOW, CRYSTALLINE POWDER
• ODORLESS
• less than 1 mg/mL at 70 °F (NTP, 1992)

Regulatory Status

GHS notification summary	1.4% (1 / 69)

GHS Hazard Classification

GHS notification summary	1.4% (1 / 69)
Reported hazard statements	H302 (20.3%), H317 (65.2%), H334 (75.4%), H351 (15.9%)

Documented Uses

• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• CONDENSATION OF 2-AMINO-6-METHYLPYRIDINE WITH DIETHYL ESTER OF (ETHOXYMETHYLENE) MALONIC ACID, THEN CYCLIZATION TO ETHYL 1 ,4-DIHYDRO-7-METHYL-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE, FOLLOWED BY ETHYLATION WITH ETHYL BROMIDE & SAPONIFICATION
• ...derived from 2-amino-6-methylpyridine.
• 20 mg/kg/day /Japanese aquaculture/
• (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS
• (1978) PROBABLY GREATER THAN 4.54X10+5 GRAMS

Synonyms

nalidixic acid; 389-08-2; Nalidixin; NegGram; Nevigramon; Nalidixan; Wintomylon; Nalidic acid; Nalidixinic acid; Dixiben; Nalurin; Naxuril; Nogram; Urisal; Nalix; 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Nalidixic acid?

CAS 389-08-2; molecular formula C12H12N2O3; molecular weight — g/mol.

What other names is Nalidixic acid known by?

nalidixic acid, 389-08-2, Nalidixin, NegGram, Nevigramon, Nalidixan.

Is Nalidixic acid classified as hazardous?

1.4% of GHS notifications report no hazard classification (1 of 69).

What are the key physical properties of Nalidixic acid?

Melting Point: 444 to 446 °F (NTP, 1992); Melting Point: 229.5; Melting Point: 229-230 °C; Melting Point: 229.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.