萘甲唑啉

Description

naphazoline · CAS 835-31-4 · C14H14N2. UNII H231GF11BV. Boiling Point: 440.466; LogP: 3.881.

Identification

CAS Registry Number	835-31-4
PubChem CID	4436
Molecular formula	C14H14N2
IUPAC name	2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
UNII (FDA)	H231GF11BV

Computed Descriptors

Molecular Weight	210.27
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	210.115698455
Monoisotopic Mass	210.115698455
Topological Polar Surface Area	24.4
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Boiling Point	440.466
LogP	3.881

Physical description & handling notes

• Solid
• 149.6 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 149.87 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 138.47 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 152.77 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 147.59 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	100% (2 / 2)

GHS Hazard Classification

GHS notification summary	100% (2 / 2)

Documented Uses

• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Naphazoline is indicated for use as OTC eyedrops for ocular vasoconstriction or as a nasal preparation for nasal congestion.
• Drugs that selectively bind to and activate alpha adrenergic receptors.
• Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
• S01G - Decongestants and antiallergics
• S01GA - Sympathomimetics used as decongestants

Synonyms

naphazoline; 835-31-4; 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole; Nafazolina; Clearine; Nafazolin; Naphazolinum; 2-(1-Naphthylmethyl)-2-imidazoline; Ciba 2020/R; alpha-Naphthylmethyl imidazoline; 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-; DTXSID3048449; H231GF11BV; DTXCID90198485; Tele Stulln; AK Con

Frequently Asked Questions

What are the CAS number and molecular formula of naphazoline?

CAS 835-31-4; molecular formula C14H14N2; molecular weight — g/mol.

What other names is naphazoline known by?

naphazoline, 835-31-4, 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole, Nafazolina, Clearine, Nafazolin.

Is naphazoline classified as hazardous?

100% of GHS notifications report no hazard classification (2 of 2).

What are the key physical properties of naphazoline?

Boiling Point: 440.466; LogP: 3.881.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.