Nefazodone HCL

Description

Nefazodone HCL · CAS 82752-99-6 · C25H32ClN5O2. UNII 59H4FCV1TF. Melting Point: 83.5; Melting Point: 83-84 °C; Melting Point: 83 - 84 °C.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• Crystals from 2-propanol/heptane
• Crystals from 2-propanol, with slow cooling yields a polymorph. MP: 186.0-187.0 °C. Also reported as crystals from ethanol. Nonhygroscopic. MP. 175-177 °C. Freely solluble in chloroform; soluble in propylene gylcol; slightly soluble in polyethylene glycol, water /Nefazodone hydrchloride/
• 32.6 [ug/mL] (The mean of the results at pH 7.4)
• Stable under recommended storage conditions. /Nefazodone hydrochloride/
• 211.7 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Documented Uses

• Antidepressive Agents, Second-Generation
• Consumption (g per capita) in the USA (2002): 0.0826
• Nefazodone (sold as Serzone, Nefadar) is a psychoactive drug and antidepressant. [wikipedia]
• Preparation: D. L. Temple, Jr., W. G. Lobeck, Jr., United States of America patent 4338317 (1982 to Mead Johnson).
• For the treatment of depression.
• Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. Nefazodone therapy has been associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to several instances of clinically apparent acute liver injury some of which have been fatal.

Synonyms

nefazodone; 83366-66-9; Nefazodona; Nefazodonum; Nefazodonum [Latin]; 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one; 59H4FCV1TF; CHEBI:7494; 1-(3-(4-(3-Chlorpheyl-1-piperazinylpropyl)-3-ethyl-4,5-dihydro-4-(2-phenoxyethyl)-1,2,4-triazol-5-on; DTXSID2023357; Nefazodonum (Latin); 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one; 3H-1,2,4-Triazol-3-one, 2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-; 1-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one; RefChem:57773; DTXCID203357

Frequently Asked Questions

What are the CAS number and molecular formula of Nefazodone HCL?

CAS 82752-99-6; molecular formula C25H32ClN5O2; molecular weight — g/mol.

What other names is Nefazodone HCL known by?

nefazodone, 83366-66-9, Nefazodona, Nefazodonum, Nefazodonum [Latin], 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one.

What are the key physical properties of Nefazodone HCL?

Melting Point: 83.5; Melting Point: 83-84 °C; Melting Point: 83 - 84 °C; Solubility: 6.98e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.