Niflumic acid

Description

Niflumic acid · CAS 4394-00-7 · C13H9F3N2O2. UNII 4U5MP5IUD8. Melting Point: 203; Melting Point: 203 °C; Solubility: 19.

Identification

CAS Registry Number	4394-00-7
PubChem CID	4488
Molecular formula	C13H9F3N2O2
IUPAC name	2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
UNII (FDA)	4U5MP5IUD8

Computed Descriptors

Molecular Weight	282.22
XLogP3	3.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	282.06161202
Monoisotopic Mass	282.06161202
Topological Polar Surface Area	62.2
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	203
Melting Point	203 °C
Solubility	19
Solubility	8.83e-02 g/L
LogP	4.43
LogP	2.95

Physical description & handling notes

• Solid
• 156.8 Ų [M+H]+ [CCS Type: TW]
• 159.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Niflumic acid, a nonsteroidal anti-inflammatory fenamate, is a Ca²⁺-activated Cl^- channel blocker.

GHS Hazard Classification

Reported hazard statements	H301 (56.6%), H302 (43.4%), H312 (43.4%), H315 (44.4%), H319 (44.4%), H332 (43.4%), H335 (43.4%), H413 (54.5%)

Documented Uses

• Used in the treatment of rheumatoid arthritis.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
• M01 - Antiinflammatory and antirheumatic products
• M01A - Antiinflammatory and antirheumatic products, non-steroids
• M01AX - Other antiinflammatory and antirheumatic agents, non-steroids

Synonyms

niflumic acid; 4394-00-7; Acido niflumico; Acide niflumique; Niflugel; UP 83; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; Acidum niflumicum; DTXSID1023368; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; UP-83; 4U5MP5IUD8; NSC-758196; DTXCID903368; 2-(3-[Trifluoromethyl]anilino)nicotinic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Niflumic acid?

CAS 4394-00-7; molecular formula C13H9F3N2O2; molecular weight — g/mol.

What other names is Niflumic acid known by?

niflumic acid, 4394-00-7, Acido niflumico, Acide niflumique, Niflugel, UP 83.

Is Niflumic acid classified as hazardous?

Hazard statements reported: H301, H302, H312, H315, H319.

What are the key physical properties of Niflumic acid?

Melting Point: 203; Melting Point: 203 °C; Solubility: 19; Solubility: 8.83e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.