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Nilotinib & its intermediates

CAS 641571-10-0C28H22F3N7OMW 529.5

Nilotinib & its intermediates (CAS No. 641571-10-0) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Chemical Intermediates. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number641571-10-0
Molecular FormulaC28H22F3N7O
Molecular Weight529.5
LogP4.9
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsChemical Intermediates
CategoryChemical Intermediates

Where it is used

Chemical Intermediates

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Nilotinib & its intermediates?

The CAS number of Nilotinib & its intermediates is 641571-10-0.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Nilotinib & its intermediates?

Main applications include Chemical Intermediates.

How do I buy Nilotinib & its intermediates or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Nilotinib & its intermediates · CAS 641571-10-0 · C28H22F3N7O. UNII F41401512X. Solubility: 2.01e-03 g/L; Dissociation Constants: pKa1 = 2.1; pKa2 = 5.4.

Identification

CAS Registry Number641571-10-0
PubChem CID644241
Molecular formulaC28H22F3N7O
IUPAC name4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
UNII (FDA)F41401512X

Computed Descriptors

Molecular Weight529.5
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass529.18379284
Monoisotopic Mass529.18379284
Topological Polar Surface Area97.6
Heavy Atom Count39
Formal Charge0

Physical & Chemical Properties

Solubility2.01e-03 g/L
Dissociation ConstantspKa1 = 2.1; pKa2 = 5.4

Physical description & handling notes

  • Solid
  • White to slightly yellowish to slightly greenish yellow powder
  • The solubility ... in aqueous solutions decreases with increasing pH
  • A monohydrate monohydrochloride
  • Nilotinib is a transduction inhibitor that targets BCR-ABL, c-kit and PDGF, for the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
  • Nilotinib preparations: (AHFS, 2010):

GHS Hazard Classification

Reported hazard statementsH361 (69.2%), H372 (15.4%), H373 (76.9%), H400 (69.2%), H410 (69.2%), H413 (23.1%)

H361 (69.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361fd (46.2%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]

Documented Uses

  • Use (kg; approx.) in Germany (2009): >75
  • Consumption (g per capita; approx.) in Germany (2009): 0.000916
  • For the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
  • Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia. Nilotinib therapy is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
  • Oral - Solid - capsule: 150 mg; 200 mg

Synonyms

Nilotinib; 641571-10-0; AMN 107; AMN-107; nilotinibum; Danziten; NSC-747599; DTXSID5042663; F41401512X; CHEBI:52172; RefChem:58968; AMN 107 Base; DTXCID3022663; L01XE08; Tasigna; AMN107

Frequently Asked Questions

What are the CAS number and molecular formula of Nilotinib & its intermediates?

CAS 641571-10-0; molecular formula C28H22F3N7O; molecular weight — g/mol.

What other names is Nilotinib & its intermediates known by?

Nilotinib, 641571-10-0, AMN 107, AMN-107, nilotinibum, Danziten.

Is Nilotinib & its intermediates classified as hazardous?

Hazard statements reported: H361, H372, H373, H400, H410.

What are the key physical properties of Nilotinib & its intermediates?

Solubility: 2.01e-03 g/L; Dissociation Constants: pKa1 = 2.1; pKa2 = 5.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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