Nilutamide

Description

Nilutamide · CAS 63612-50-0 · C12H10F3N3O4. UNII 51G6I8B902. Solubility: 4.19e-03 g/L; LogP: 1.8; LogP: 2.31.

Identification

CAS Registry Number	63612-50-0
PubChem CID	4493
Molecular formula	C12H10F3N3O4
IUPAC name	5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
UNII (FDA)	51G6I8B902

Computed Descriptors

Molecular Weight	317.22
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	317.06234029
Monoisotopic Mass	317.06234029
Topological Polar Surface Area	95.2
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Solubility	4.19e-03 g/L
LogP	1.8
LogP	2.31

Physical description & handling notes

• Solid
• 162.8 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID3034165]

GHS Hazard Classification

Reported hazard statements	H301 (100%), H360 (97.6%)

Documented Uses

• For use in combination with surgical castration for the treatment of metastatic prostate cancer involving distant lymph nodes, bone, or visceral organs (Stage D2).
• Nilutamide is a first generation, oral nonsteroidal antiandrogen similar in structure to flutamide that is used in the therapy of prostate cancer. Nilutamide is associated with a low rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent, acute liver injury.
• Malignant neoplasms of prostate
• Nilutamide is approved to treat:
• • Prostate cancer that has metastasized (spread to other parts of the body). It is used in patients who have had surgery to remove the testicles (orchiectomy).
• Take separate from meals. Take before breakfast.

Synonyms

nilutamide; 63612-50-0; Anandron; Nilandron; 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione; Nilutamida; Nilutamidum; 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione; RU-23908; RU 23908; 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin; DTXSID3034165; NSC-758683; 51G6I8B902; 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-imidazolidinedione; 2,4-IMIDAZOLIDINEDIONE, 5,5-DIMETHYL-3-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)-

Frequently Asked Questions

What are the CAS number and molecular formula of Nilutamide?

CAS 63612-50-0; molecular formula C12H10F3N3O4; molecular weight — g/mol.

What other names is Nilutamide known by?

nilutamide, 63612-50-0, Anandron, Nilandron, 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione, Nilutamida.

Is Nilutamide classified as hazardous?

Hazard statements reported: H301, H360.

What are the key physical properties of Nilutamide?

Solubility: 4.19e-03 g/L; LogP: 1.8; LogP: 2.31.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.