硝唑尼特

Description

Nitazoxanide · CAS 55981-09-4 · C12H9N3O5S. UNII SOA12P041N. Boiling Point: 394; Melting Point: 202; Melting Point: 202 °C.

Identification

CAS Registry Number	55981-09-4
PubChem CID	41684
Molecular formula	C12H9N3O5S
IUPAC name	[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
UNII (FDA)	SOA12P041N

Computed Descriptors

Molecular Weight	307.28
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	307.02629157
Monoisotopic Mass	307.02629157
Topological Polar Surface Area	142
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Boiling Point	394
Melting Point	202
Melting Point	202 °C
Solubility	0.000189
Solubility	7.55e-03 g/L
LogP	1.63
LogP	1.2
LogP	2.41

Physical description & handling notes

• Solid

Regulatory Status

GHS notification summary	4.3% (2 / 47)

GHS Hazard Classification

GHS notification summary	4.3% (2 / 47)
Reported hazard statements	H302 (95.7%), H315 (95.7%), H319 (95.7%), H335 (93.6%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia, and for the treatment of diarrhea in children caused by the protozoan, Cryptosporidium parvum. Nitazoxanide has not been shown to be superior to placebo medication for the management of diarrhea caused by Cryptosporidium parvum in patients with HIV/immunodeficiency.
• Nitazoxanide is an antimicrobial with activity against several parasitic worms and protozoa that is used predominantly in the United States in treatment of giardiasis and cryptosporidiosis. Nitazoxanide therapy has not been reported to cause serum aminotransferase elevations during therapy or clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiparasitic Agents
• Take with food. Food improves oral bioavailability.
• Drugs used to treat or prevent parasitic infections.

Synonyms

NITAZOXANIDE; 55981-09-4; Alinia; Nitazoxanida; Nitazoxanidum; Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-; 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate; 2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl)benzamide; DTXSID5033757; NSC697855; NSC-697855; NSC-760057; PH 5776; PH-5776; SOA12P041N; Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester)

Frequently Asked Questions

What are the CAS number and molecular formula of Nitazoxanide?

CAS 55981-09-4; molecular formula C12H9N3O5S; molecular weight — g/mol.

What other names is Nitazoxanide known by?

NITAZOXANIDE, 55981-09-4, Alinia, Nitazoxanida, Nitazoxanidum, Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-.

Is Nitazoxanide classified as hazardous?

4.3% of GHS notifications report no hazard classification (2 of 47).

What are the key physical properties of Nitazoxanide?

Boiling Point: 394; Melting Point: 202; Melting Point: 202 °C; Solubility: 0.000189.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.