nomifensine maleate

Description

nomifensine maleate · CAS 24526-64-5 · C16H18N2. UNII 1LGS5JRP31. Melting Point: 180; Melting Point: 179-181 °C.

Identification

CAS Registry Number	24526-64-5
PubChem CID	4528
Molecular formula	C16H18N2
IUPAC name	2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
UNII (FDA)	1LGS5JRP31

Computed Descriptors

Molecular Weight	238.33
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	238.146998583
Monoisotopic Mass	238.146998583
Topological Polar Surface Area	29.3
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	180
Melting Point	179-181 °C

Physical description & handling notes

• When heated decomposition it emits toxic fumes of NOx.
• 155.8 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0023377]
• 156.2 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0023377]
• 154.65 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 155.15 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 157.41 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H301 (100%), H315 (100%), H318 (100%), H335 (100%)

Documented Uses

• Novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.
• Preparation: GB 1164192 corresp to G. Ehrhart at al., US 3577424 (1969, 1971, both to Farbwerke Hoechst)
• Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal Register of June 17, 1986 (51 FR 21981)). Approval of the NDA for Merital capsules was withdrawn on March 20, 1992 (see the Federal Register of March 20, 1992 (57 FR 9729)). Also
• Nomifensine, introduced in 1985, is a tetrahydroisoquinoline antidepressant. /No longer approved for use in the US/
• The development of sudden fever in 6 women and one man (mean age, 64 yr) during oral nomifensine therapy at usual doses is reported. During original therapy, fever occurred within 2 wk (range, a few hr to 30 days) and sooner during a second treatment (one to 3 days). In 6 cases, the recurrence of the fever closely following the rechallenge is suggestive of a causal relationship and implies a hypersensitivity reaction.
• In humans, nomifensine has been found to mildly elevate heart rate but not to affect orthostatic blood pressure, QRS width, QT interval, or the His-bundle electrocardiogram at doses up to 200 mg/day for three weeks.

Synonyms

Nomifensine; 24526-64-5; nomifensin; Linamiphen; (+-)-Nomifensin; (+-)-Nomifensine; Nomifensina; Nomifensinum; 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-; D,L-nomifensine; 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline; 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine; DTXSID0023377; 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine; 1LGS5JRP31; Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-

Frequently Asked Questions

What are the CAS number and molecular formula of nomifensine maleate?

CAS 24526-64-5; molecular formula C16H18N2; molecular weight — g/mol.

What other names is nomifensine maleate known by?

Nomifensine, 24526-64-5, nomifensin, Linamiphen, (+-)-Nomifensin, (+-)-Nomifensine.

Is nomifensine maleate classified as hazardous?

Hazard statements reported: H301, H315, H318, H335.

What are the key physical properties of nomifensine maleate?

Melting Point: 180; Melting Point: 179-181 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.