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Description

Oteseconazole · CAS 1340593-59-0 · C23H16F7N5O2. UNII VHH774W97N.

Identification

CAS Registry Number	1340593-59-0
PubChem CID	77050711
Molecular formula	C23H16F7N5O2
IUPAC name	(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(2,2,2-trifluoroethoxy)phenyl]-2-pyridinyl]propan-2-ol
UNII (FDA)	VHH774W97N

Computed Descriptors

Molecular Weight	527.4
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	8
Exact Mass	527.11922190
Monoisotopic Mass	527.11922190
Topological Polar Surface Area	86
Heavy Atom Count	37
Formal Charge	0

Physical description & handling notes

• Insoluble at a pH range of 1 to 9

GHS Hazard Classification

Reported hazard statements	H302 (50%), H373 (50%)

Documented Uses

• Oteseconazole is an azole antifungal indicated to reduce the incidence of recurrent vulvovaginal candidiasis (RVVC) in females with a history of RVVC who are not of reproductive potential.
• Breast Feeding; Lactation; Milk, Human; Antifungal Agents; Dermatologic Agents
• Oteseconazole is an antifungal prescription medicine approved by the Food and Drug Administration (FDA) to reduce the risk of recurrent vulvovaginal candidiasis in females who are not pregnant and who are not able to become pregnant.
• Vulvovaginal candidiasis can be an opportunistic infection (OI) of HIV.
• Take with food. Oteseconazole must be taken with food, and capsules must be swallowed whole and not chewed, crushed, dissolved, or opened. The intake of high-fat, high-calorie meals (800-1000 Calories; 50% fat) increases oteseconazole C_max and AUC_0-72h by 45% and 36%, respectively. No significant differences were detected when oteseconazole was administered with a low-fat, low-calorie meal.
• Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

Synonyms

Oteseconazole; 1340593-59-0; VT-1161; VIVJOA; oteseconazol; VHH774W97N; oteseconazolum; RefChem:57369; Oteseconazole [USAN]; CHEMBL3311228; CHEBI:188153; D87154; C23H16F7N5O2; Vivijoa (TN); Oteseconazole [MI]; Oteseconazole (Standard)

Frequently Asked Questions

What are the CAS number and molecular formula of Oteseconazole?

CAS 1340593-59-0; molecular formula C23H16F7N5O2; molecular weight — g/mol.

What other names is Oteseconazole known by?

Oteseconazole, 1340593-59-0, VT-1161, VIVJOA, oteseconazol, VHH774W97N.

Is Oteseconazole classified as hazardous?

Hazard statements reported: H302, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.