柠檬酸帕克替尼

Description

Pacritinib citrate · CAS 1228923-42-9 · C34H40N4O10. UNII VJ2PH4NXX7.

Identification

CAS Registry Number	1228923-42-9
PubChem CID	46216795
Molecular formula	C34H40N4O10
IUPAC name	2-hydroxypropane-1,2,3-tricarboxylic acid;(16E)-11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene
UNII (FDA)	VJ2PH4NXX7

Computed Descriptors

Molecular Weight	664.7
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	9
Exact Mass	664.27444349
Monoisotopic Mass	664.27444349
Topological Polar Surface Area	201
Heavy Atom Count	48
Formal Charge	0
Complexity	871

GHS Hazard Classification

Reported hazard statements	H373 (100%)

Documented Uses

• Pacritinib citrate is approved to treat adults with:
• • Myelofibrosis (a bone marrow disease) that is intermediate or high risk with a very low platelet count, including the following types:
• • Post-polycythemia vera myelofibrosis.
• • Post-essential thrombocythemia myelofibrosis.
• Pacritinib citrate is approved under FDA’s Accelerated Approval Program. As a condition of approval, confirmatory trial(s) must show that it provides a clinical benefit in these patients.Pacritinib citrate is also being studied in the treatment of other conditions.

Synonyms

Pacritinib citrate; Vonjo; 1228923-42-9; VJ2PH4NXX7; SB1518 CITRATE; SB-1518 CITRATE; UNII-VJ2PH4NXX7; Epjevy; RefChem:58093; Pacritinib (citrate); SB 1518 citrate; Pacritinib citrate [MI]; Pacritinib citrate [WHO-DD]; orb2565590; CHEMBL5095049; CHEBI:231412

Frequently Asked Questions

What are the CAS number and molecular formula of Pacritinib citrate?

CAS 1228923-42-9; molecular formula C34H40N4O10; molecular weight — g/mol.

What other names is Pacritinib citrate known by?

Pacritinib citrate, Vonjo, 1228923-42-9, VJ2PH4NXX7, SB1518 CITRATE, SB-1518 CITRATE.

Is Pacritinib citrate classified as hazardous?

Hazard statements reported: H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.