硫酸巴龙霉素

Description

Paromomycin sulfate · CAS 1263-89-4 · C23H45N5O14. UNII 61JJC8N5ZK. Solubility: 7.97e+01 g/L.

Identification

CAS Registry Number	1263-89-4
PubChem CID	165580
Molecular formula	C23H45N5O14
IUPAC name	(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol
UNII (FDA)	61JJC8N5ZK

Computed Descriptors

Molecular Weight	615.6
XLogP3	-8.7
Hydrogen Bond Donor Count	13
Hydrogen Bond Acceptor Count	19
Rotatable Bond Count	9
Exact Mass	615.29630113
Monoisotopic Mass	615.29630113
Topological Polar Surface Area	347
Heavy Atom Count	42
Formal Charge	0

Physical & Chemical Properties

Solubility	7.97e+01 g/L

Physical description & handling notes

• Solid
• 237.7 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 239.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• Paromomycin is a broad spectrum aminoglycoside antibiotic produced by <i>Streptomyces rimosus</i> var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Amebicides; Anti-Bacterial Agents; Aminoglycosides
• Antiamoebic and antigiardiasis medicines
• (1) Oral - Liquid: 125 mg per 5 mL as sulfate; (2) Oral - Solid: 250 mg as sulfate

Synonyms

paromomycin; Aminosidin; catenulin; Monomycin A; 7542-37-2; Neomycin E; Hydroxymycin; Crestomycin; Paucimycin; AMINOSIDINE; Paromomycine; Estomycin; Quintomycin C; Paromomycin I; Zygomycin A1; Gabromycin

Frequently Asked Questions

What are the CAS number and molecular formula of Paromomycin sulfate?

CAS 1263-89-4; molecular formula C23H45N5O14; molecular weight — g/mol.

What other names is Paromomycin sulfate known by?

paromomycin, Aminosidin, catenulin, Monomycin A, 7542-37-2, Neomycin E.

What are the key physical properties of Paromomycin sulfate?

Solubility: 7.97e+01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.