Pefloxacin

Description

Pefloxacin · CAS 70458-92-3 · C17H20FN3O3. UNII 2H52Z9F2Q5. Melting Point: 271; Melting Point: 271 °C; Solubility: 11.4.

Identification

CAS Registry Number	70458-92-3
PubChem CID	51081
Molecular formula	C17H20FN3O3
IUPAC name	1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
UNII (FDA)	2H52Z9F2Q5

Computed Descriptors

Molecular Weight	333.36
XLogP3	0.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	333.14886967
Monoisotopic Mass	333.14886967
Topological Polar Surface Area	64.1
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	271
Melting Point	271 °C
Solubility	11.4
Solubility	1.23e+00 g/L
LogP	0.27
LogP	2.4
LogP	0.31
Collision Cross Section	178.17 Ų [M+H]+
Collision Cross Section	192.96 Ų [M+Na]+

Physical description & handling notes

• Solid
• 171.62 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 189.29 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 189.38 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 194.2 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 188.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (100%), H319 (100%), H335 (100%)

Documented Uses

• For the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
• Substances that inhibit the growth or reproduction of BACTERIA.
• Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
• Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2.
• J - Antiinfectives for systemic use
• J01 - Antibacterials for systemic use

Synonyms

Pefloxacin; 70458-92-3; Pefloxacine; 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Pefloxacino; Pefloxacinum; PFLX; AM-725; 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 1589 RB; EU-5306; 1589-RB; CHEBI:50199; 2H52Z9F2Q5; DTXSID3048493; 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

Frequently Asked Questions

What are the CAS number and molecular formula of Pefloxacin?

CAS 70458-92-3; molecular formula C17H20FN3O3; molecular weight — g/mol.

What other names is Pefloxacin known by?

Pefloxacin, 70458-92-3, Pefloxacine, 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Pefloxacino, Pefloxacinum.

Is Pefloxacin classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

What are the key physical properties of Pefloxacin?

Melting Point: 271; Melting Point: 271 °C; Solubility: 11.4; Solubility: 1.23e+00 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.