Pemigatinib

Name: Pemigatinib
Brand: Jinan Shenghe Chemical Co., Ltd.

CAS 1513857-77-6C24H27F2N5O4MW 487.5

Pemigatinib (CAS No. 1513857-77-6) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1513857-77-6

Molecular FormulaC24H27F2N5O4

Molecular Weight487.5

LogP1.8

Purity按批次COA提供(不公开发布)

Packaging按订单/批次确认(不公开发布)

ApplicationsOrganic Chemicals

CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)

Purity按批次COA提供(不公开发布)

StorageSealed, cool and dry place

Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Pemigatinib?

The CAS number of Pemigatinib is 1513857-77-6.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Pemigatinib?

Main applications include Organic Chemicals.

How do I buy Pemigatinib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Pemigatinib · CAS 1513857-77-6 · C24H27F2N5O4. UNII Y6BX7BL23K.

Identification

CAS Registry Number	1513857-77-6
PubChem CID	86705695
Molecular formula	C24H27F2N5O4
IUPAC name	11-(2,6-difluoro-3,5-dimethoxyphenyl)-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraen-12-one
UNII (FDA)	Y6BX7BL23K

Computed Descriptors

Molecular Weight	487.5
XLogP3	1.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	487.20311068
Monoisotopic Mass	487.20311068
Topological Polar Surface Area	83.2
Heavy Atom Count	35
Formal Charge	0

Documented Uses

Pemigatinib is indicated for the treatment of unresectable locally advanced or metastatic cholangiocarcinoma in previously-treated adult patients with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test. It is also indicated for the treatment of adults with relapsed or refractory myeloid/lymphoid neoplasms (MLNs) with FGFR1 rearrangement.
Pemigatinib is a fibroblast growth factor (FGF) receptor kinase inhibitor that is used to treat unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma, as well as myeloid or lymphoid neoplasms with FGFR rearrangements. Pemigatinib is associated with transient and usually mild-to-moderate elevations in serum aminotransferase levels during therapy, but has not been convincingly linked to cases of clinically apparent liver injury with jaundice.
Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors
Pemigatinib is approved to treat adults with:
• Cholangiocarcinoma (bile duct cancer) that has spread or cannot be removed by surgery. It is used in patients whose cancer has already been treated and has an FGFR2gene fusion or other change in the structure of the FGFR2 gene.¹
• Myeloid or lymphoid cancer that has come back or did not respond to treatment and has a certain change in the structure of the FGFR1 gene.

Synonyms

Pemigatinib; 1513857-77-6; Pemazyre; INCB054828; Fgfr inhibitor INCB054828; Y6BX7BL23K; INCB-054828; DTXSID501027955; pemigatinibum; RefChem:58318; DTXCID401513523; Pemigatinib [INN]; Pemigatinib [USAN]; INCB54828; INCB-54828; UNII-Y6BX7BL23K

Frequently Asked Questions

What are the CAS number and molecular formula of Pemigatinib?

CAS 1513857-77-6; molecular formula C24H27F2N5O4; molecular weight — g/mol.

What other names is Pemigatinib known by?

Pemigatinib, 1513857-77-6, Pemazyre, INCB054828, Fgfr inhibitor INCB054828, Y6BX7BL23K.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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