Penciclovir

Description

Penciclovir · CAS 39809-25-1 · C10H15N5O3. UNII 359HUE8FJC. Melting Point: 275-277 °C; Melting Point: 275-277 °C ... /also reported as/ 272-275 °C; Melting Point: 275 - 277 °C.

Identification

CAS Registry Number	39809-25-1
PubChem CID	135398748
Molecular formula	C10H15N5O3
IUPAC name	2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one
UNII (FDA)	359HUE8FJC

Computed Descriptors

Molecular Weight	253.26
XLogP3	-1.9
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	253.11748936
Monoisotopic Mass	253.11748936
Topological Polar Surface Area	126
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	275-277 °C
Melting Point	275-277 °C ... /also reported as/ 272-275 °C
Melting Point	275 - 277 °C
Solubility	1.7mg/ml
Solubility	7.45e+00 g/L
LogP	-1.1

Physical description & handling notes

• Solid
• White crystalline solid from water (monohydrate) ... also reported as colorless matted needles
• Occurs as monohydrate, stable crystalline solid. Solubility in water (20deg C): >200 mg/mL, 30 mg/mL solution has pH 11/Penciclovir sodium salt/
• Solubility in water at 20 °C: 1.7 mg/mL, pH 7
• When heated to decomposition material emits toxic fumes of /nitrogen oxides/. /Famciclovir/
• pKa1= 3.2 (-NH); pKa2 = 9.4 (-NH2)

GHS Hazard Classification

Reported hazard statements	H319 (100%)

Documented Uses

• THERAPEUTIC CATEGORY: Antiviral
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents
• Antiviral Agents; Reverse Transcriptase Inhibitors

Synonyms

penciclovir; 39809-25-1; Denavir; BRL-39123; Penciclovirum; Vectavir; BRL 39123; 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one; 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine; CCRIS 9213; DTXSID9046491; 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE; 359HUE8FJC; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; NSC-759624; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine

Frequently Asked Questions

What are the CAS number and molecular formula of Penciclovir?

CAS 39809-25-1; molecular formula C10H15N5O3; molecular weight — g/mol.

What other names is Penciclovir known by?

penciclovir, 39809-25-1, Denavir, BRL-39123, Penciclovirum, Vectavir.

Is Penciclovir classified as hazardous?

Hazard statements reported: H319.

What are the key physical properties of Penciclovir?

Melting Point: 275-277 °C; Melting Point: 275-277 °C ... /also reported as/ 272-275 °C; Melting Point: 275 - 277 °C; Solubility: 1.7mg/ml.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.