Petinimid

Description

Petinimid · CAS 77-67-8 · C7H11NO2. UNII 5SEH9X1D1D. Melting Point: 64.5; Melting Point: 64 - 65 °C; Melting Point: 64.5 °C.

Identification

CAS Registry Number	77-67-8
PubChem CID	3291
Molecular formula	C7H11NO2
IUPAC name	3-ethyl-3-methylpyrrolidine-2,5-dione
UNII (FDA)	5SEH9X1D1D

Computed Descriptors

Molecular Weight	141.17
XLogP3	0.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	141.078978594
Monoisotopic Mass	141.078978594
Topological Polar Surface Area	46.2
Heavy Atom Count	10
Formal Charge	0

Physical & Chemical Properties

Melting Point	64.5
Melting Point	64 - 65 °C
Melting Point	64.5 °C
Solubility	39.2
Solubility	1.01e+02 g/L
LogP	0.38
LogP	log Kow = 0.38
LogP	0.1
LogP	0.23

Physical description & handling notes

• Solid
• Crystals from acetone and ether
• WHITE TO OFF-WHITE CRYSTALLINE POWDER OR WAXY SOLID
• CHARACTERISTIC ODOR
• Freely soluble in water
• VERY SLIGHTLY SOL IN SOLVENT HEXANE

GHS Hazard Classification

Reported hazard statements	H302 (95.7%)

Documented Uses

• For the treatment of petit mal epilepsy.
• The condensation of butanone with cyano ethyl acetate and subsequent reaction with NaCN and H2SO4 gives 2-ethyl-2-methyl-succinic acid, which is ring-closed via the diammonium salt to yield ethosuximide.
• Methyl ethyl ketone + ethyl cyanoacetate + hydrogen cyanide + ammonia (Cope reaction/addition/nitrile hydrolysis/decarboxylation/ester hydrolysis/amide formation)
• (1972) LESS THAN 10+7 GRAMS (CONSUMPTION EST)
• Ethosuximide is FDA-approved for the management of absence seizures in patients 3 or older. Additionally, several studies have suggested ethosuximide may also have some analgesic effects, making it a potential therapy for neuropathic pain.
• Ethosuximide is an succinimide based anticonvulsant commonly used for absence (petit mal) seizures in both adults and children. Ethosuximide has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice.

Synonyms

ethosuximide; 77-67-8; Zarontin; Etosuximida; 3-Ethyl-3-methylpyrrolidine-2,5-dione; 2-Ethyl-2-methylsuccinimide; Ethosuxide; Pyknolepsinum; Emeside; Suxilep; Ethosuccimide; Ethosuccinimide; Atysmal; Suxinutin; Etosuximid; Petinimid

Frequently Asked Questions

What are the CAS number and molecular formula of Petinimid?

CAS 77-67-8; molecular formula C7H11NO2; molecular weight — g/mol.

What other names is Petinimid known by?

ethosuximide, 77-67-8, Zarontin, Etosuximida, 3-Ethyl-3-methylpyrrolidine-2,5-dione, 2-Ethyl-2-methylsuccinimide.

Is Petinimid classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Petinimid?

Melting Point: 64.5; Melting Point: 64 - 65 °C; Melting Point: 64.5 °C; Solubility: 39.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.