苯乙西林钾

Description

phenethicillin potassium · CAS 132-93-4 · C17H19KN2O5S. UNII 70978WUK7C. Stability/Shelf Life: DECOMP AT 230-232 °C. /DL-FORM/.

Identification

CAS Registry Number	132-93-4
PubChem CID	23675317
Molecular formula	C17H19KN2O5S
IUPAC name	potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxypropanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
UNII (FDA)	70978WUK7C

Computed Descriptors

Molecular Weight	402.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	402.06517437
Monoisotopic Mass	402.06517437
Topological Polar Surface Area	124
Heavy Atom Count	26
Formal Charge	0
Complexity	582

Physical & Chemical Properties

Stability/Shelf Life	DECOMP AT 230-232 °C. /DL-FORM/

Physical description & handling notes

• White crystalline solid
• Very soluble in water
• VERY RESISTANT TO DECOMP IN ACIDIC SOLN.
• MODERATELY HYGROSCOPIC.
• CRYSTALS FROM ACETONE; FREELY SOLUBLE IN WATER; MUCH LESS HYGROSCOPIC THAN BENZYLPENICILLIN SODIUM /DL-FORM/
• CRYSTALS FROM 20% BUTANOL; SPECIFIC OPTICAL ROTATION: +218 DEG @ 24 °C/D (WATER, 0.01%) /L-FORM, EPIPHENETHICILLIN POTASSIUM, L-MAXIPEN POTASSIUM/

GHS Hazard Classification

Reported hazard statements	H317 (100%), H334 (100%)

Documented Uses

• PHENETHICILLIN IS PREPD FROM 6-AMINOPENICILLANIC ACID.
• THIS CONGENER OF PENICILLIN IS PHENOXYETHYL ANALOG OF PENICILLIN G. ... STABILITY IN ACIDIC MEDIA & BETTER ABSORPTION FROM GI TRACT...IS ITS SOLE ADVANTAGE IN COMPARISON TO PENICILLIN G. IT IS AVAIL ONLY FOR ORAL USE & HENCE IS NOT SUBSTITUTE FOR PARENTERAL PENICILLIN, WHEN SUCH THERAPY IS INDICATED. /PHENETHICILLIN/
• GINGIVOSTOMATITIS, PULMONARY INFECTIONS, & GENITAL DISEASE PRODUCED BY SYNERGISTIC ACTION OF FUSOBACTERIUM NUCLEATUM (FUSIFORM) & SPIROCHETES PRESENT IN RESPIRATORY TRACT ARE READILY TREATABLE WITH PENICILLIN. /PENICILLIN/
• PENICILLIN PROPHYLAXIS OF PROVEN VALUE. STREPTOCOCCAL INFECTIONS...RHEUMATIC FEVER RECURRENCES...GONORRHEA...SYPHILIS...SURGICAL PROCEDURES IN PATIENTS WITH VALVULAR HEART DISEASE. /PENICILLIN/
• ...PENICILLIN CAN MARKEDLY ALTER NORMAL BACTERIAL FLORA OF MAN. ... SUPERIMPOSED INFECTION BY PENICILLIN-RESISTANT MICROORGANISM MAY DEVELOP... VERY HIGH CONCN OF PENICILLIN ARE NEUROTOXIC... /PENICILLIN/
• MECHANISM MOST COMMONLY INVOLVED IN PATHOGENESIS OF UNTOWARD EFFECTS FROM ANY TYPE OF PENICILLIN IS HYPERSENSITIZATION. ALLERGIC REACTIONS TO PENICILLINS VARY FROM 0.7 TO 10%... /PENICILLINS/

Synonyms

phenethicillin potassium; Pheneticillin potassium; Astracillin; Maxipen; Oralopen; 132-93-4; Penova; Potassium phenethicillin; Feneticilline; Synthecillin; Synthecilline; Alfacillin; Alticina; Bendralan; Brocsil; Penemve

Frequently Asked Questions

What are the CAS number and molecular formula of phenethicillin potassium?

CAS 132-93-4; molecular formula C17H19KN2O5S; molecular weight — g/mol.

What other names is phenethicillin potassium known by?

phenethicillin potassium, Pheneticillin potassium, Astracillin, Maxipen, Oralopen, 132-93-4.

Is phenethicillin potassium classified as hazardous?

Hazard statements reported: H317, H334.

What are the key physical properties of phenethicillin potassium?

Stability/Shelf Life: DECOMP AT 230-232 °C. /DL-FORM/.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.