pheniramine

Description

pheniramine · CAS 86-21-5 · C16H20N2. UNII 134FM9ZZ6M. Boiling Point: 181; Boiling Point: 175.00 °C. @ 25.00 mm Hg; Melting Point: 107.

Identification

CAS Registry Number	86-21-5
PubChem CID	4761
Molecular formula	C16H20N2
IUPAC name	N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
UNII (FDA)	134FM9ZZ6M

Computed Descriptors

Molecular Weight	240.34
XLogP3	2.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	240.162648646
Monoisotopic Mass	240.162648646
Topological Polar Surface Area	16.1
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Boiling Point	181
Boiling Point	175.00 °C. @ 25.00 mm Hg
Melting Point	107
Melting Point	< 25 °C
Solubility	3.77e-01 g/L

Physical description & handling notes

• Solid
• 158.44 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 156.75 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 154.64 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 149.7 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Pheniramine acts as an antagonist to allergic symptoms stemming from inappropriate histamine release to reduce edema, itching, and redness. The same antihistamine effect also produces sedation by acting in the central nervous system.

GHS Hazard Classification

Reported hazard statements	H300 (97.5%)

Documented Uses

• Pharmaceuticals -> Dermatologicals -> Antihistamines
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Pheniramine is commonly used in over-the-counter products to treat seasonal allergies or cold and flu symptoms.
• Pheniramine has known transformation products that include Pheniramine-N-oxide and N-Desmethylpheniramine.
• Pheniramine is a known transformation product of Pheniramine-N-oxide.
• Agents, usually topical, that relieve itching (pruritus).

Synonyms

pheniramine; Prophenpyridamine; Tripoton; Pyriton; 86-21-5; Propheniramine; Feniramina; Pheniraminum; dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine; 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; NSC-47965; 134FM9ZZ6M; 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-; DTXSID0023454; Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-; dimethyl(3-phenyl-3-(pyridin-2-yl)propyl)amine

Frequently Asked Questions

What are the CAS number and molecular formula of pheniramine?

CAS 86-21-5; molecular formula C16H20N2; molecular weight — g/mol.

What other names is pheniramine known by?

pheniramine, Prophenpyridamine, Tripoton, Pyriton, 86-21-5, Propheniramine.

Is pheniramine classified as hazardous?

Hazard statements reported: H300.

What are the key physical properties of pheniramine?

Boiling Point: 181; Boiling Point: 175.00 °C. @ 25.00 mm Hg; Melting Point: 107; Melting Point: < 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.