Pheniramine Maleate

Description

Pheniramine Maleate · CAS 132-20-7 · C16H20N2.C4H4O4. UNII NYW905655B. Melting Point: 219 to 226 °F (NTP, 1992).

Identification

CAS Registry Number	132-20-7
PubChem CID	5282139
Molecular formula	C16H20N2.C4H4O4
IUPAC name	(Z)-but-2-enedioic acid;N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
UNII (FDA)	NYW905655B

Computed Descriptors

Molecular Weight	356.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	356.17360725
Monoisotopic Mass	356.17360725
Topological Polar Surface Area	90.7
Heavy Atom Count	26
Formal Charge	0
Complexity	340

Physical & Chemical Properties

Melting Point	219 to 226 °F (NTP, 1992)

Physical description & handling notes

• Pheniramine maleate is a white powder with a faint amine-like odor. Melting point 107 °C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistamine.
• Soluble (>=10 mg/ml at 75 °F) (NTP, 1992)
• 155.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (90.3%)

Documented Uses

• 2-Pyridinepropanamine, N,N-dimethyl-.gamma.-phenyl-, (2Z)-2-butenedioate (1:1): ACTIVE
• Agents, usually topical, that relieve itching (pruritus).
• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Synonyms

PHENIRAMINE MALEATE; 132-20-7; Inhiston; Trimeton; Trimetose; Daneral; Naphcon a; Pheniramine hydrogen maleate; Prophenpyridamine maleate; Antolozine; Fervex; Avil-retard; PM 241; 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate; NSC-757270; HO 11513

Frequently Asked Questions

What are the CAS number and molecular formula of Pheniramine Maleate?

CAS 132-20-7; molecular formula C16H20N2.C4H4O4; molecular weight — g/mol.

What other names is Pheniramine Maleate known by?

PHENIRAMINE MALEATE, 132-20-7, Inhiston, Trimeton, Trimetose, Daneral.

Is Pheniramine Maleate classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Pheniramine Maleate?

Melting Point: 219 to 226 °F (NTP, 1992).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.