苯氧苯甲明

Description

phenoxybenzamine · CAS 59-96-1 · C18H22ClNO. UNII 0TTZ664R7Z. Melting Point: 39; Melting Point: 38-40 °C; Melting Point: 39 °C.

Identification

CAS Registry Number	59-96-1
PubChem CID	4768
Molecular formula	C18H22ClNO
IUPAC name	N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine
UNII (FDA)	0TTZ664R7Z

Computed Descriptors

Molecular Weight	303.8
XLogP3	4.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Exact Mass	303.1389920
Monoisotopic Mass	303.1389920
Topological Polar Surface Area	12.5
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	39
Melting Point	38-40 °C
Melting Point	39 °C
Solubility	1.03e-02 g/L
LogP	4.7

Physical description & handling notes

• Solid
• CRYSTALS FROM PETROLEUM ETHER
• Melting point: 137.5-140 °C /Phenoxybenzamine hydrochloride/
• WHITE CRYSTALLINE POWDER; SOL IN 9 PARTS CHLOROFORM; INSOL IN DIETHYLETHER /PHENOXYBENZAMINE HYDROCHLORIDE/
• CRYSTALS FROM ALC & ETHER; SOL IN ALC, PROPYLENE GLYCOL; VERY SPARINGLY SOL IN WATER /PHENOXYBENZAMINE HYDROCHLORIDE/
• SOL IN BENZENE

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• REACTION OF 2-PHENOXY-1-METHYL ETHANOL WITH THIONYL CHLORIDE, FOLLOWED BY REACTION WITH ETHANOLAMINE, BENZYL CHLORIDE, & THIONYL CHLORIDE
• Phenoxybenzamine is available only as the hydrochloride.
• Phenoxybenzamine hydrochloride has been produced by a single company in the USA since 1953, in an undisclosed amount. /Phenoxybenzamine hydrochloride/
• For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.

Synonyms

phenoxybenzamine; Dibenylin; 59-96-1; Bensylyt; Dibenyline; Benzylyt; Fenoxibenzamina; Dibenylene; Fenossibenzamina; Phenoxybenzaminum; 688A; Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine; NSC 37448; A 688; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine

Frequently Asked Questions

What are the CAS number and molecular formula of phenoxybenzamine?

CAS 59-96-1; molecular formula C18H22ClNO; molecular weight — g/mol.

What other names is phenoxybenzamine known by?

phenoxybenzamine, Dibenylin, 59-96-1, Bensylyt, Dibenyline, Benzylyt.

What are the key physical properties of phenoxybenzamine?

Melting Point: 39; Melting Point: 38-40 °C; Melting Point: 39 °C; Solubility: 1.03e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.