pilocarpine

Description

pilocarpine · CAS 92-13-7 · C11H16N2O2. UNII 01MI4Q9DI3. Melting Point: 195-205; Melting Point: 34 °C; Solubility: 2.07e+00 g/L.

Identification

CAS Registry Number	92-13-7
PubChem CID	5910
Molecular formula	C11H16N2O2
IUPAC name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
UNII (FDA)	01MI4Q9DI3

Computed Descriptors

Molecular Weight	208.26
XLogP3	1.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	208.121177757
Monoisotopic Mass	208.121177757
Topological Polar Surface Area	44.1
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Melting Point	195-205
Melting Point	34 °C
Solubility	2.07e+00 g/L
LogP	-3.03
LogP	1.1
LogP	0.66
Dissociation Constants	PK1= 7.15; PK2= 12.57 @ 20 °C

Physical description & handling notes

• Solid
• OIL OR CRYSTALS
• NEEDLES
• 260 °C @ 5 MM HG (PARTIAL CONVERSION TO ISOPILOCARPINE)
• FREELY SOL IN ETHANOL; INSOL IN DIETHYL ETHER /HCL/
• SOL IN WATER, ALC, CHLOROFORM; SPARINGLY SOL IN ETHER, BENZENE; ALMOST INSOL IN PETROLEUM ETHER

GHS Hazard Classification

Reported hazard statements	H300, H330, H310, H370

Documented Uses

• Use (kg; approx.) in Germany (2009): >75
• Consumption (g per capita; approx.) in Germany (2009): 0.000916
• For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
• TOTAL ALKALOIDS ARE EXTRACTED FROM...SUITABLE PILOCARPUS SPECIES, WITH ALC CONTAINING SMALL AMT OF HYDROCHLORIC ACID. SOLVENT DISTD OFF...RESINS ARE ALL DEPOSITED. ...FILTERED...EVAPORATED TO SMALL BULK. AMMONIA IS ADDED IN EXCESS & FREE ALKALOIDS EXTRACTED WITH CHLOROFORM.
• PREOBRASHENSKI ET AL, BER 66, 1187 (1933); SAMOKH ALOV, MED PROM SSSR 11, NO 2, 10 (1957)...
• 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-: ACTIVE

Synonyms

pilocarpine; 92-13-7; Pilokarpin; Pilocarpol; Syncarpine; Ocusert pilo; Pilocarpin; Spersacarpine; Ocusert pilo-20; Ocusert Pilo-40; Ocusert P 20; ocucarpine; Pilocarpine muriate; Pilovisc; Pilocarpinum; DTXSID1021162

Frequently Asked Questions

What are the CAS number and molecular formula of pilocarpine?

CAS 92-13-7; molecular formula C11H16N2O2; molecular weight — g/mol.

What other names is pilocarpine known by?

pilocarpine, 92-13-7, Pilokarpin, Pilocarpol, Syncarpine, Ocusert pilo.

Is pilocarpine classified as hazardous?

Hazard statements reported: H300, H330, H310, H370.

What are the key physical properties of pilocarpine?

Melting Point: 195-205; Melting Point: 34 °C; Solubility: 2.07e+00 g/L; LogP: -3.03.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.