Pramipexole

Description

Pramipexole · CAS 104632-26-0 · C10H17N3S. UNII 83619PEU5T. Boiling Point: 378; Melting Point: 288-290; Solubility: 1.40e-01 g/L.

Identification

CAS Registry Number	104632-26-0
PubChem CID	119570
Molecular formula	C10H17N3S
IUPAC name	(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
UNII (FDA)	83619PEU5T

Computed Descriptors

Molecular Weight	211.33
XLogP3	1.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	211.11431873
Monoisotopic Mass	211.11431873
Topological Polar Surface Area	79.2
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Boiling Point	378
Melting Point	288-290
Solubility	1.40e-01 g/L
LogP	1.42
LogP	0.4
Dissociation Constants	5.6, 9.5

Physical description & handling notes

• Solid
• freely soluble in water
• Stable under recommended storage conditions. /Pramipexole dihydrochloride/
• Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Sulfur oxides, Hydrogen chloride gas. /Pramipexole dihydrochloride/
• 152.8 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID1044227]
• 152.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID1044227]

Regulatory Status

GHS notification summary	16.7% (1 / 6)

GHS Hazard Classification

GHS notification summary	16.7% (1 / 6)
Reported hazard statements	H302 (66.7%), H312 (16.7%), H315 (16.7%), H317 (33.3%), H319 (16.7%), H332 (16.7%), H412 (50%)

Documented Uses

• Antioxidants; Antiparkinson Agents; Dopamine Agonists
• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• For the treatment of signs and symptoms of idiopathic Parkinson's disease
• Butanal and 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole are heated in DMF and the imine reduced with sodium borohydride; water is added and acidified to pH 1, extracted with ethyl acetate, which is discarded. The aqueous phase is made alkaline with potassium carbonate, extracted with ethyl acetate, dried, concentrated and the salt precipitated with ethereal HCl.
• Preparation of racemate: G. Griss et al., European Patent Office patent 186087; eidem, United States of America patent 4886812 (1986, 1989 both to Thomae).

Synonyms

pramipexole; 104632-26-0; (-)-Pramipexole; Pramipexol; Mirapexin; Pramipexolum; Sifrol; SUD919CL2Y; Mirapex; U-98528E; (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; Pramipexolum [Latin]; DTXSID6023496; (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; SUD-919CL2Y; CTC-501

Frequently Asked Questions

What are the CAS number and molecular formula of Pramipexole?

CAS 104632-26-0; molecular formula C10H17N3S; molecular weight — g/mol.

What other names is Pramipexole known by?

pramipexole, 104632-26-0, (-)-Pramipexole, Pramipexol, Mirapexin, Pramipexolum.

Is Pramipexole classified as hazardous?

16.7% of GHS notifications report no hazard classification (1 of 6).

What are the key physical properties of Pramipexole?

Boiling Point: 378; Melting Point: 288-290; Solubility: 1.40e-01 g/L; LogP: 1.42.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.