普拉莫卡因

Description

pramocaine · CAS 140-65-8 · C17H27NO3. UNII 068X84E056. LogP: 3.56.

Identification

CAS Registry Number	140-65-8
PubChem CID	4886
Molecular formula	C17H27NO3
IUPAC name	4-[3-(4-butoxyphenoxy)propyl]morpholine
UNII (FDA)	068X84E056

Computed Descriptors

Molecular Weight	293.4
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	293.19909372
Monoisotopic Mass	293.19909372
Topological Polar Surface Area	30.9
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

LogP	3.56

Physical description & handling notes

• 177.42 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 160.85 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 174.13 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Pramocaine temporarily relieves pain, pruritis, burning and discomfort associated with minor lip and skin irritations and hemorrhoid's by inhibiting voltage gated sodium channels on neurons.

Documented Uses

• It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
• C05A - Agents for treatment of hemorrhoids and anal fissures for topical use
• D04 - Antipruritics, incl. antihistamines, anesthetics, etc.
• D04A - Antipruritics, incl. antihistamines, anesthetics, etc.
• D04AB - Anesthetics for topical use
• QC05A - Agents for treatment of hemorrhoids and anal fissures for topical use

Synonyms

Pramocaine; pramoxine; 140-65-8; Proxazocain; 4-[3-(4-Butoxyphenoxy)propyl]morpholine; pramocainum; Pramocaina; 4-(3-(p-Butoxyphenoxy)propyl)morpholine; p-Butoxyphenyl gamma-morpholinopropyl ether; gamma-Morpholinopropyl 4-n-butoxyphenyl ether; 4-(3-(4-butoxyphenoxy)propyl)morpholine; CHEBI:8357; 068X84E056; DTXSID8040692; RefChem:55901; DTXCID6020692

Frequently Asked Questions

What are the CAS number and molecular formula of pramocaine?

CAS 140-65-8; molecular formula C17H27NO3; molecular weight — g/mol.

What other names is pramocaine known by?

Pramocaine, pramoxine, 140-65-8, Proxazocain, 4-[3-(4-Butoxyphenoxy)propyl]morpholine, pramocainum.

What are the key physical properties of pramocaine?

LogP: 3.56.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.