Quinapril hydrochloride

Description

Quinapril hydrochloride · CAS 82586-55-8 · C25H31ClN2O5. UNII 33067B3N2M.

Identification

Computed Descriptors

Physical description & handling notes

• 120-130 °C (crystals from ethyl acetatetoluene) and 119-121.5 °C (crystals from acetonitrile)
• >71.2 [ug/mL] (The mean of the results at pH 7.4)
• 203.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Crystals from ethyl acetate-toluene ... /with/ specific optical rotation at 23 °C for D (sodium) line = +14.5 deg (c = 1.2 in ethanol). Also reported as white crystalline solid from acetonitrile ... /with/ specific optical rotation at 25 °C for D (sodium) line = +15.4 deg (c = 2 in methanol).
• White to off-white amorphous powder that is freely soluble in aqueous solvents
• CI-906; PD-109452-2; Accupril; Accuprin; Accupro; Acequin; Acuitel; Korec; Quinazil

GHS Hazard Classification

Documented Uses

• For the treatment of hypertension and as adjunct therapy in the treatment of congestive heart failure. May also be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
• Preparation: M.L. Hoefle, S. Klutchko, EP 49605; eidem, US 4344949 (both 1982 to Warner-Lambert)...Synthesis of novel crystalline and purified form: O.P. Goel, U. Krolls, US 4761479 (1988 to Warner-Lambert)
• The main ingredient in the drug Accuretic ... (tablets) /Mixture with Hydrochlorothiazide/
• ... /Quinapril/ has proven to be very useful for the treatment of hypertension ... . /Salt not specified/
• The combination of ... quinapril and hydrochlorothiazide is indicated in the treatment of hypertension. Fixed-dosage combinations generally are not recommended for initial therapy, but are utilized in maintenance therapy after the required dose is established in order to increase convenience, economy, and patient compliance. /Included in US product labeling/ /Salt not specified/
• Angiotensin converting enzyme (ACE) inhibitor /Salt not specified/

Synonyms

QUINAPRIL HYDROCHLORIDE; 82586-55-8; QUINAPRIL HCL; Korec; Accuprin; Quinazil; Acequin; Acuitel; Hemokvin; Accupro; CI-906; DTXSID3021221; CI 906; NSC-758222; 33067B3N2M; CHEBI:8714

Frequently Asked Questions

What are the CAS number and molecular formula of Quinapril hydrochloride?

CAS 82586-55-8; molecular formula C25H31ClN2O5; molecular weight — g/mol.

What other names is Quinapril hydrochloride known by?

QUINAPRIL HYDROCHLORIDE, 82586-55-8, QUINAPRIL HCL, Korec, Accuprin, Quinazil.

Is Quinapril hydrochloride classified as hazardous?

Hazard statements reported: H361.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.