盐酸奎扎替尼

Description

Quizartinib hydrochloride · CAS 1132827-21-4 · C29H34Cl2N6O4S. UNII WK7Q6ZIZ10.

Identification

CAS Registry Number	1132827-21-4
PubChem CID	25184035
Molecular formula	C29H34Cl2N6O4S
IUPAC name	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea;dihydrochloride
UNII (FDA)	WK7Q6ZIZ10

Computed Descriptors

Molecular Weight	633.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	632.1739301
Monoisotopic Mass	632.1739301
Topological Polar Surface Area	134
Heavy Atom Count	42
Formal Charge	0
Complexity	849

Documented Uses

• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors
• Quizartinib dihydrochloride is approved to treat:
• • Acute myeloid leukemia that is newly diagnosed and has a certain mutation in the FLT3 gene. It is used in adults, first with cytarabine and an anthracycline drug as induction therapy, next with cytarabine as consolidation therapy, and then alone as maintenance therapy.
• Quizartinib dihydrochloride is only available as part of a special program called Vanflyta REMS (Risk Evaluation and Mitigation Strategies).

Synonyms

Quizartinib dihydrochloride; 1132827-21-4; AC-220 dihydrochloride; vanflyta; AC010220.2HCL; WK7Q6ZIZ10; AC220 2HCL; AC010220 2HCL; AC-010220 DIHYDROCHLORIDE; DTXSID30150345; RefChem:56997; DTXCID7072836; Quizartinib (dihydrochloride); Quizartinib dihydrochloride [USAN]; Quizartinib dihydrochloride (USAN); UNII-WK7Q6ZIZ10

Frequently Asked Questions

What are the CAS number and molecular formula of Quizartinib hydrochloride?

CAS 1132827-21-4; molecular formula C29H34Cl2N6O4S; molecular weight — g/mol.

What other names is Quizartinib hydrochloride known by?

Quizartinib dihydrochloride, 1132827-21-4, AC-220 dihydrochloride, vanflyta, AC010220.2HCL, WK7Q6ZIZ10.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.