riluzole

Description

riluzole · CAS 1744-22-5 · C8H5F3N2OS. UNII 7LJ087RS6F. Melting Point: 119; Melting Point: 119 °C; Solubility: 3.95e-02 g/L.

Identification

CAS Registry Number	1744-22-5
PubChem CID	5070
Molecular formula	C8H5F3N2OS
IUPAC name	6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
UNII (FDA)	7LJ087RS6F

Computed Descriptors

Molecular Weight	234.20
XLogP3	3.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	234.00746845
Monoisotopic Mass	234.00746845
Topological Polar Surface Area	76.4
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Melting Point	119
Melting Point	119 °C
Solubility	3.95e-02 g/L
LogP	2.3
LogP	3.34

Physical description & handling notes

• Solid
• 22.1 [ug/mL] (The mean of the results at pH 7.4)

GHS Hazard Classification

Reported hazard statements	H301 (91.9%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
• Riluzole is a neuroprotective agent used for therapy of amyotrophic lateral sclerosis. Riluzole is associated with a low rate of serum aminotransferase elevations during therapy and has been linked to rare instances of clinically apparent, acute liver injury.
• Breast Feeding; Lactation; Excitatory Amino Acid Antagonists; Neuroprotective Agents
• Amyotrophic Lateral Sclerosis Agents

Synonyms

riluzole; 1744-22-5; Rilutek; 2-Amino-6-(trifluoromethoxy)benzothiazole; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; Riluzol; RP-54274; Riluzolum; 2-amino-6-trifluoromethoxybenzothiazole; 2-Benzothiazolamine, 6-(trifluoromethoxy)-; RP 54274; Tiglutik; NSC-753433; NSC-759823; EXSERVAN; 7LJ087RS6F

Frequently Asked Questions

What are the CAS number and molecular formula of riluzole?

CAS 1744-22-5; molecular formula C8H5F3N2OS; molecular weight — g/mol.

What other names is riluzole known by?

riluzole, 1744-22-5, Rilutek, 2-Amino-6-(trifluoromethoxy)benzothiazole, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, Riluzol.

Is riluzole classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of riluzole?

Melting Point: 119; Melting Point: 119 °C; Solubility: 3.95e-02 g/L; LogP: 2.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.