罗拉吡坦

Description

Rolapitant · CAS 552292-08-7 · C25H26F6N2O2. UNII NLE429IZUC.

Identification

CAS Registry Number	552292-08-7
PubChem CID	10311306
Molecular formula	C25H26F6N2O2
IUPAC name	(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one
UNII (FDA)	NLE429IZUC

Computed Descriptors

Molecular Weight	500.5
XLogP3	4.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	500.18984705
Monoisotopic Mass	500.18984705
Topological Polar Surface Area	50.4
Heavy Atom Count	35
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H361 (100%)

Documented Uses

• This drug is indicated in adults in combination with other antiemetics for the prevention of delayed nausea and vomiting associated with emetogenic chemotherapy.
• Rolapitant is an orally available antiemetic agent that is used to prevent cancer chemotherapy related nausea and vomiting. Rolapitant therapy has not been associated with serum enzyme elevations or with instances of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Milk, Human; Antiemetics; Neurokinin-1 Receptor Antagonists
• Avoid St. John's Wort. This herb induces CYP3A metabolism and may reduce serum levels of rolapitant.
• Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
• Mechanisms of Action [MoA] - Neurokinin 1 Antagonists

Synonyms

Rolapitant; 552292-08-7; NLE429IZUC; Varuby; (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one; CHEBI:90908; A04AD14; DTXSID90203740; (5S,8S)-8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro(4.5)decan-2-one; (5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one; (5S,8S)-8-{[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl}-8-phenyl-1,7-diazaspiro[4.5]decan-2-one; 1,7-DIAZASPIRO(4.5)DECAN-2-ONE, 8-(((1R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHOXY)METHYL)-8-PHENYL-, (5S,8S)-; rolapitantum; (5S,8S)-8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,9-diazaspiro(4.5)decan-2-one; RefChem:57237; DTXCID20126231

Frequently Asked Questions

What are the CAS number and molecular formula of Rolapitant?

CAS 552292-08-7; molecular formula C25H26F6N2O2; molecular weight — g/mol.

What other names is Rolapitant known by?

Rolapitant, 552292-08-7, NLE429IZUC, Varuby, (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one, CHEBI:90908.

Is Rolapitant classified as hazardous?

Hazard statements reported: H361.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.