rosuvastatin

Description

rosuvastatin · CAS 287714-41-4 · C22H28FN3O6S. UNII 413KH5ZJ73. Solubility: 8.86e-02 g/L; LogP: 0.13; LogP: 2.4.

Identification

CAS Registry Number	287714-41-4
PubChem CID	446157
Molecular formula	C22H28FN3O6S
IUPAC name	(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
UNII (FDA)	413KH5ZJ73

Computed Descriptors

Molecular Weight	481.5
XLogP3	1.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	481.16828496
Monoisotopic Mass	481.16828496
Topological Polar Surface Area	149
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Solubility	8.86e-02 g/L
LogP	0.13
LogP	2.4
Ionization Efficiency	2.53
Ionization Efficiency	2.7
Ionization Efficiency	MeCN (80%)

Physical description & handling notes

• Solid
• Sparingly soluble in water
• Kow = 0.13 (pH 7.0) /log Kow = -0.88/
• Stable under recommended storage conditions. /Rosuvastatin calcium/
• White powder from water as the monohydrate; begins to melt at 155 °C with no definitive MP. Specific optical rotation: +14.8 deg at 24 °C/D (c = 1.012 in 50% methanol). Sparingly soluble in water, methanol; slightly soluble in ethanol /Rosuvastatin calcium salt/
• Positive

GHS Hazard Classification

Reported hazard statements	H351 (90%), H360 (90%), H411 (10%), H412 (90%)

Documented Uses

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease.
• Preparation: K. Hirai et al., European Patent Office patent 521471; eidem, United States of America patent 5260440 (both 1993 to Shionogi).
• Rosuvastatin is a lipid-lowering statin medication classified as a moderate- to high-intensity statin based on its efficacy in reducing low-density lipoprotein cholesterol (LDL-C) levels.

Synonyms

Rosuvastatin; 287714-41-4; Creston; X-Plended; ZD4522; Rosuvastatina; ZD-4522; 413KH5ZJ73; DTXSID8048492; CHEBI:38545; rosuvastatinum; RefChem:6205; C10AA07; DTXCID90820057; rosuvastatine; Rosuvastatin [INN]

Frequently Asked Questions

What are the CAS number and molecular formula of rosuvastatin?

CAS 287714-41-4; molecular formula C22H28FN3O6S; molecular weight — g/mol.

What other names is rosuvastatin known by?

Rosuvastatin, 287714-41-4, Creston, X-Plended, ZD4522, Rosuvastatina.

Is rosuvastatin classified as hazardous?

Hazard statements reported: H351, H360, H411, H412.

What are the key physical properties of rosuvastatin?

Solubility: 8.86e-02 g/L; LogP: 0.13; LogP: 2.4; Ionization Efficiency: 2.53.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.