水杨酰水杨酸

Description

salicylylsalicylic acid · CAS 552-94-3 · C14H10O5. UNII V9MO595C9I. Melting Point: 147; Melting Point: 147 °C; Solubility: 2.46e-01 g/L.

Identification

CAS Registry Number	552-94-3
PubChem CID	5161
Molecular formula	C14H10O5
IUPAC name	2-(2-hydroxybenzoyl)oxybenzoic acid
UNII (FDA)	V9MO595C9I

Computed Descriptors

Molecular Weight	258.23
XLogP3	3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	258.05282342
Monoisotopic Mass	258.05282342
Topological Polar Surface Area	83.8
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	147
Melting Point	147 °C
Solubility	2.46e-01 g/L

Physical description & handling notes

• Solid
• 151.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 153.86 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 157.62 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 169.52 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 146.85 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (87.2%), H315 (14.9%), H319 (14.9%), H335 (10.6%), H400 (80.9%)

Documented Uses

• Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester: INACTIVE
• For relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.
• Salsalate is a nonacetylated dimer of salicylic acid that is used in the treatment of chronic arthritis as an analgesic and antipyretic. Salsalate can cause moderate serum aminotransferase elevations when given in high doses in a manner similar to aspirin.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal
• Avoid excessive or chronic alcohol consumption. Ingesting alcohol may increase the risk of developing a gastrointestinal bleed.
• Take with or without food. Taking salsalate with food may slow the absorption of salsalate but does not significantly impact the Cmax or AUC.

Synonyms

Salsalate; 552-94-3; sasapyrine; Salicylsalicylic acid; Disalcid; 2-Carboxyphenyl salicylate; Disalicylic acid; Sasapyrinum; Sasapyrin; 2-(2-hydroxybenzoyl)oxybenzoic acid; 2-((2-Hydroxybenzoyl)oxy)benzoic acid; Disalicylsaeure; Salsalato; Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; Salicylic acid, bimolecular ester; Salsalatum

Frequently Asked Questions

What are the CAS number and molecular formula of salicylylsalicylic acid?

CAS 552-94-3; molecular formula C14H10O5; molecular weight — g/mol.

What other names is salicylylsalicylic acid known by?

Salsalate, 552-94-3, sasapyrine, Salicylsalicylic acid, Disalcid, 2-Carboxyphenyl salicylate.

Is salicylylsalicylic acid classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H400.

What are the key physical properties of salicylylsalicylic acid?

Melting Point: 147; Melting Point: 147 °C; Solubility: 2.46e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.