司美替尼

Name: 司美替尼
Brand: 济南圣和化工有限公司

CAS 606143-52-6C17H15BrClFN4O3MW 457.7

司美替尼，CAS 登记号 606143-52-6，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于有机化学品。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号606143-52-6

分子式C17H15BrClFN4O3

分子量457.7

LogP3.6

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域有机化学品

类别有机化学品

用途与场景

有机化学品

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

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本页已列出司美替尼的 CAS 号：606143-52-6，可与随货 COA 核对。

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主要涉及有机化学品。

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PubChem 公开数据

Description

Selumetinib · CAS 606143-52-6 · C17H15BrClFN4O3. UNII 6UH91I579U.

Identification

CAS Registry Number	606143-52-6
PubChem CID	10127622
Molecular formula	C17H15BrClFN4O3
IUPAC name	6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
UNII (FDA)	6UH91I579U

Computed Descriptors

Molecular Weight	457.7
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	456.00001
Monoisotopic Mass	456.00001
Topological Polar Surface Area	88.4
Heavy Atom Count	27
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H302 (40%), H317 (80%), H318 (60%), H361 (80%), H373 (80%), H411 (60%), H413 (20%)

H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]

H317 (80%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Documented Uses

Selumetinib is indicated for the treatment of neurofibromatosis type 1 (NF1) in adult and pediatric patients one year of age and older who have symptomatic, inoperable plexiform neurofibromas (PN).
Selumetinib is an oral, small molecule inhibitor of the mitogen activated protein kinase 1 and 2 (MEK1/2) that is used to treat symptomatic, refractory fibromas in neurofibromatosis type 1. Selumetinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury.
Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Tyrosine Kinase Inhibitors; Signal Transduction Inhibitors; MEK Inhibitors
Genetic Disorder Agents, Antineoplastic Agents
Take on an empty stomach. Avoid consuming food 2 hours before and 1 hour after each dose.
Established Pharmacologic Class [EPC] - Kinase Inhibitor

Synonyms

Selumetinib; 606143-52-6; AZD6244; ARRY-142886; 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE; AZD 6244; AZD-6244; ARRY-886; selumetinibum; DTXSID3048944; 6UH91I579U; ARRY142886; DTXCID0028870; CHEBI:90227; 1H-Benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-; 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

Frequently Asked Questions

What are the CAS number and molecular formula of Selumetinib?

CAS 606143-52-6; molecular formula C17H15BrClFN4O3; molecular weight — g/mol.

What other names is Selumetinib known by?

Selumetinib, 606143-52-6, AZD6244, ARRY-142886, 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE, AZD 6244.

Is Selumetinib classified as hazardous?

Hazard statements reported: H302, H317, H318, H361, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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