Sulfadoxine

Description

Sulfadoxine · CAS 2447-57-6 · C12H14N4O4S. UNII 88463U4SM5. Melting Point: 190-194 °C; Melting Point: 190 - 194 °C; Solubility: 2.96e-01 g/L.

Identification

CAS Registry Number	2447-57-6
PubChem CID	17134
Molecular formula	C12H14N4O4S
IUPAC name	4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
UNII (FDA)	88463U4SM5

Computed Descriptors

Molecular Weight	310.33
XLogP3	0.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	310.07357611
Monoisotopic Mass	310.07357611
Topological Polar Surface Area	125
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	190-194 °C
Melting Point	190 - 194 °C
Solubility	2.96e-01 g/L
LogP	0.7
LogP	0.70
Collision Cross Section	173.22 Ų [M-H]-

Physical description & handling notes

• Solid
• 165.3 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 166.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 172.96 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 173.77 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 165.22 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H315 (57.7%), H317 (43.8%), H319 (57.7%), H335 (55.4%), H400 (22.3%), H410 (22.3%), H411 (42.3%)

Documented Uses

• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.
• Take after a meal. Taking sulfadoxine with food, may reduce gastrointestinal irritation.
• Take with a full glass of water.
• Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
• Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.

Synonyms

SULFADOXINE; 2447-57-6; Sulphadoxine; Sulfadoxin; Sulforthomidine; 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide; Sulphormethoxine; Sulfadoxinum; Sulfadoxina; Fanzil; Ro 4-4393; Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-; Fanasulf; 4-Sulfanilamido-5,6-dimethoxypyrimidine; DTXSID6023608; Ro-4-4393

Frequently Asked Questions

What are the CAS number and molecular formula of Sulfadoxine?

CAS 2447-57-6; molecular formula C12H14N4O4S; molecular weight — g/mol.

What other names is Sulfadoxine known by?

SULFADOXINE, 2447-57-6, Sulphadoxine, Sulfadoxin, Sulforthomidine, 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide.

Is Sulfadoxine classified as hazardous?

Hazard statements reported: H315, H317, H319, H335, H400.

What are the key physical properties of Sulfadoxine?

Melting Point: 190-194 °C; Melting Point: 190 - 194 °C; Solubility: 2.96e-01 g/L; LogP: 0.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.